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Antiviral agents and verruca

Discussion in 'General Issues and Discussion Forum' started by Cameron, Aug 10, 2006.

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  1. Cameron

    Cameron Well-Known Member


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    I am interested to know if anyone has used antiviral preparations on plantar warts.

    Cameron

    Toutous-Trellu L, Hirschel B, Piguet V, Schiffer V, Saurat JH, Pechere M.
    [Treatment of cutaneous human papilloma virus, poxvirus and herpes simplex virus infections with topical cidofovir in HIV positive patients]
    Ann Dermatol Venereol. 2004 May;131(5):445-9.

    INTRODUCTION: Cidofovir (Vistide) is an antiviral marketed for the treatment of cytomegalovirus retinitis. Clinical efficacy has been reported with its broad antiviral spectrum that includes poxvirus, human papilloma virus and Herpes simplex. In immunodepressed patients, these infectious dermatoses are often recurrent and resistant. In an open study, we assessed the efficacy and clinical tolerance of cidofovir gel at 1 p. 100. PATIENTS AND METHODS: Twelve HIV-infected adults were included. Cidofovir gel at 1 p. 100 was applied directly on the lesions, once a day, for two weeks on the molluscum and condylomas, four weeks on the warts and one week on the chronic herpes. RESULTS: Four patients presented with warts and 3 of them with verruca plana. In 2 of the verruca plana patients, regression was complete although relapse was observed. Two failures were noted. Local application of the gel was not tolerated by one patient suffering from condylomas of the penis. Four patients presented with molluscum contagiosum. Two complete regressions with strong local reaction and two partial regressions were observed. The latter two patients exhibited severe immunodepression, one of them subsequently received infusions of cidofovir. Two women suffering from vulvar and perianal herpes resistant to acyclovir were treated for one week with cidofovir gel at 1 p. 100: no response was obtained. One of the patients stopped treatment because of local intolerance. A third, less immunodepressed, woman responded partially. COMMENTS: In HIV-positive patients, cidofovir in topical form appears to be indicated in extensive and confluent molluscum contagiosum. However, the effect occurs at the cost of local inflammation. The results are disappointing in papillomavirus lesions and in chronic acyclovir-resistant herpes ulcerations, efficacy is debatable.
     
  2. Admin2

    Admin2 Administrator Staff Member

  3. Cameron

    Cameron Well-Known Member

    Much appreciated Admin2 and I also sympathise with the cross postings and runaway themes you have to deal with, but on this occassion I do not think your "related themes" has really much to do with the question I originally posed.

    Repsectfully
    Cameron
     
  4. Admin2

    Admin2 Administrator Staff Member

    Yes, Cameron you are right they are not related to the "antiviral" but they are related to 'verruca'. Thats why I try to had all the "related" threads. Its done for the visitors with an interest in the topic rather than to answer the original questions. If a new thread is directly related to a previous one, the boss merges them. If the new thread is not directly related he leaves it to me to find all the ones related for visitors to follow if they are intested.

    Andy
     
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