Melanoma of the foot

NewsBot · Jun 15, 2023

Establishment of a prognostic model for melanoma based on necroptosis-related genes
Xiaohui Sui et al
Funct Integr Genomics. 2023 Jun 14;23(3):202

In this study, the clinical implications and potential functions of necroptosis-related genes (NRGs) in melanoma were systematically characterized. A novel NRG signature was then constructed to analyze the immune status and prognosis of patients with melanoma. The NRG signatures for melanoma prognosis were searched using the Cancer Genome Atlas (TCGA) dataset and followed by stepwise Cox regression analysis. Patients with melanoma were divided into two groups, and survival analysis, receiver operating characteristic (ROC), and univariate and multivariate analyses were subsequently performed. The correlation of risk score (RS) with tumor immunity and RT-polymerase chain reaction (PCR) was analyzed to further verify the gene signatures. Data on tumor mutational burden (TMB) and chromosomal copy number variation (CNV) were analyzed. Three NRGs were identified as prognostic risk signatures and were significantly related to overall survival (OS) in melanoma. The signatures had better diagnostic accuracy. Furthermore, analysis of mutations in the NRGs and the incidence of chromosomal CNV helped to reveal the relationship between mutations and melanoma occurrence. A nomogram was established based on RSs. The risk characteristics were significantly associated with immunity and high risk is closely correlated with melanoma development. In vitro experiments revealed that necrostatin-1 (Nec-1) promoted cell viability and repressed the expression levels of interleukin (IL)12A and proprotein convertase subtilisin/kexin type (PCSK)1. Additionally, the expression levels of IL12A, CXCL10, and PCSK1 decreased in tumor tissues of melanoma patients. NRGs exert vital roles in immunity and might be applied as a prognostic factor of melanoma.
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NewsBot · Sep 12, 2023

Metastatic melanoma to the proximal ureter
Matthew DeSanto et al
Urol Case Rep. 2023 Aug 24;

We present an exceptionally rare scenario of obstructive uropathy secondary to a ureteral mass. This case details a 68-year-old female with metastatic stage IIID melanoma of the right heel found to have a two cm right proximal ureteral mass with associated hydronephrosis. Pathology from ureteroscopic biopsy revealed metastatic melanoma to the ureter, creating a unique treatment quandary.
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NewsBot · Feb 24, 2024

The Value of Anterolateral Thigh Free Flap for the Reconstruction of Malignant Melanoma of the Sole of the Foot
Yong Chan Bae, Joo Hyoung Kim, Changryul Claud Yi
Ann Plast Surg. 2024 Jan 9

Background: Wide excision of malignant melanoma on the foot usually results in an extensive function-destroying defect, and the reconstruction of foot defects remains challenging for reconstructive surgeons. We propose using anterolateral thigh perforator (ALT) free flaps for the reconstruction of widespread defects caused by malignant melanoma in the sole.

Methods: This retrospective study included 34 patients who underwent reconstruction of sole defects caused by malignant melanoma resection with 35 ALT perforator free flaps between August 2005 and July 2021.

Results: In total, 18 male patients and 16 female patients were included (mean age at surgery, 65.4 years). The mean size of the flaps was 100.4 cm2. Thirty-three of the 35 flaps survived. Hematoma, seroma, and chronic ulceration were not identified in any cases. All patients achieved independent ambulation within the follow-up period, except 1 patient with gait discomfort. The 5-year overall and disease-free survival rates of patients were 64.4% and 56.6%, respectively.

Conclusions: The ALT flap is a versatile surgical option that should be considered for reconstruction of the sole after malignant melanoma resection, considering its various surgical advantages and the functional aspects of independent ambulation, the aesthetic aspects of wearing conventional footwear, and the anatomical aspects of the sole.
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Melanoma of the foot

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NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

Malignant Melanoma Misdiagnosed as a Diabetic Foot Ulcer

Dermoscopy as a technique for the early identification of foot melanoma

Amelanotic melanoma misdiagnosed as a diabetic foot ulcer

Melanoma

Liability in the context of misdiagnosis of melanoma as a plantar wart

Subungual/ feet Melanoma Mortality rates in Australia

bpac NZ Journal for Primary Healthcare and article Melanoma

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Melanoma of the foot

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

Malignant Melanoma Misdiagnosed as a Diabetic Foot Ulcer

Dermoscopy as a technique for the early identification of foot melanoma

Amelanotic melanoma misdiagnosed as a diabetic foot ulcer

Melanoma

Liability in the context of misdiagnosis of melanoma as a plantar wart

Subungual/ feet Melanoma Mortality rates in Australia

bpac NZ Journal for Primary Healthcare and article Melanoma

Share This Page

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