Microneedle dressing the treatment of chronic wounds

NewsBot · Feb 8, 2022

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Synergistically detachable microneedle dressing for programmed treatment of chronic wound
Tianqin Ning et al
Adv Healthc Mater. 2022 Feb 8

Chronic wounds such as diabetic foot, undergo a lifetime risk of developing into incurable ulcers. Current treatments for bacteria-infected chronic wounds remain unsatisfactory due to the lack of ideal wound dressings that integrate facile dressing change, long-acting treatment, and high therapeutic efficacy into one system. Herein, we present a synergistically detachable microneedle (MN) dressing with a dual-layer dressing structure to enable long-acting treatment via one-time dressing application. Such dual-layer dressing MNs system (DDMNS) is composed of chitosan (CS) hydrogel dressing (CSHD) on top of a detachable MNs patch with a CS tip and a polyvinyl pyrrolidone (PVP) backing substrate incorporated with magnesium (Mg). The synergistic detachment is achieved with the backing Mg/PVP substrate disappearing within 5 min due to the local moist environment of the CSHD enhancing the reaction between Mg and inflammation microenvironment, with CS tips implanted inside the wound. Mg and panax notoginseng saponins (PNS) are loaded in the DDMNS as the active pharmaceutical ingredient (API) to facilitate programmed treatment of chronic wounds with multistage drug delivery (burst release of Mg within minutes; prolonged release of PNS over 10 days). The combined treatment of PNS and Mg achieves antibacterial, neovascularization, and regulating the macrophage polarization, thereby regulating the microenvironment of the wound bed, so that the three overlapping periods of the inflammatory response, tissue proliferation, and tissue remodeling of skin injury healing reach a dynamic balance. This advanced DDMNS provides a facile approach for the programmed treatment of chronic wound management indicating their potential value in wound healing and other related biomedical fields
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