The Role of Platelet-Rich Plasma in Inducing Musculoskeletal Tissue Healing
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Brian C. Halpern, Salma Chaudhury and Scott A. Rodeo
HSS Journal; DOI: 10.1007/s11420-011-9239-7
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Postural stability and foot orthoses
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Acute:chronic workload ratio and lower extremity overuse injuries
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Platelet Rich Plasma for plantar fasciitis
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Other threads tagged with platelet rich plasmaLast edited by a moderator: May 8, 2012 -
Efficacy of Autologous Platelet-Rich Plasma Use for Orthopaedic Indications: A Meta-Analysis
Ujash Sheth, BHSc; Nicole Simunovic, MSc; Guy Klein, DO; Freddie Fu, MD; Thomas A. Einhorn, MD; Emil Schemitsch, MD; Olufemi R. Ayeni, MD; Mohit Bhandari, MD, PhD
The Journal of Bone & Joint Surgery. 2012; 94:298-307 doi:10.2106/JBJS.K.00154
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Platelet-Rich Plasma Differs According to Preparation Method and Human Variability
Augustus D. Mazzocca, MS, MD; Mary Beth R. McCarthy, BS; David M. Chowaniec, BS; Mark P. Cote, DPT; Anthony A. Romeo, MD; James P. Bradley, MD; Robert A. Arciero, MD; Knut Beitzel, MD
The Journal of Bone & Joint Surgery. 2012; 94:308-316 doi:10.2106/JBJS.K.00430
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The National Institute for Health and Clinical Excellence (NICE) issued full guidance to the NHS in England, Wales, Scotland and Northern Ireland on Autologous blood injection for tendinopathy today.
Andre -
Patellar Tendon Healing With Platelet-Rich Plasma: A Prospective Randomized Controlled Trial
Adriano Marques de Almeida et al
Am J Sports Med April 2, 2012
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Platelet-rich plasma
Blood product used in transfusion medicinePlatelet-rich plasma (PRP), also known as autologous conditioned plasma, is a concentrate of platelet-rich plasma protein derived from whole blood, centrifuged to remove red blood cells. Though promoted to treat an array of medical problems, evidence for benefit is mixed as of 2020, with some evidence for use in certain conditions and against use in other conditions.[1][2][3]
As a concentrated source of blood plasma and autologous conditioned plasma, PRP contains several different growth factors and other cytokines that can stimulate healing of soft tissue and joints. There are some indications for use in sports medicine and orthopedics (acute muscle strains, tendinopathy and muscle-fascial injuries and osteoarthritis[4]), or dermatology (androgenic alopecia, wound healing, and skin rejuvenation) or even in proctology (fistula-in-ano[5]).[6] For preparation of PRP, various protocols are used, with an underlying principle of concentrating platelets to 3–5 times physiological levels, then injecting this concentrate in the tissue where healing is desired.[7] Besides the use in clinical practice PRP has been utilized for various tissue engineering applications in the context of bone, cartilage, skin, and soft tissue repair. It has been reviewed to serve as a source for the "delivery of growth factors and/or cells within tissue-engineered constructs, often in combination with biomaterials".[8]
- ^ Xu, Q; Chen, J; Cheng, L (July 2019). "Comparison of platelet rich plasma and corticosteroids in the management of lateral epicondylitis: A meta-analysis of randomized controlled trials". International Journal of Surgery (London, England). 67: 37–46. doi:10.1016/j.ijsu.2019.05.003. PMID 31128316.
- ^ Belk, JW; Kraeutler, MJ; Houck, DA; Goodrich, JA; Dragoo, JL; McCarty, EC (17 April 2020). "Platelet-Rich Plasma Versus Hyaluronic Acid for Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials". The American Journal of Sports Medicine. 49 (1): 249–260. doi:10.1177/0363546520909397. PMID 32302218. S2CID 215809299.
- ^ Hurley, ET; Hannon, CP; Pauzenberger, L; Fat, DL; Moran, CJ; Mullett, H (May 2019). "Nonoperative Treatment of Rotator Cuff Disease With Platelet-Rich Plasma: A Systematic Review of Randomized Controlled Trials". Arthroscopy: The Journal of Arthroscopic & Related Surgery. 35 (5): 1584–1591. doi:10.1016/j.arthro.2018.10.115. PMID 31000394. S2CID 122575307.
- ^ Smith, Patrick A. (2016-04-01). "Intra-articular Autologous Conditioned Plasma Injections Provide Safe and Efficacious Treatment for Knee Osteoarthritis: An FDA-Sanctioned, Randomized, Double-blind, Placebo-controlled Clinical Trial". The American Journal of Sports Medicine. 44 (4): 884–891. doi:10.1177/0363546515624678. ISSN 1552-3365. PMID 26831629. S2CID 42338794.
- ^ de la Portilla, F.; Segura-Sampedro, J. J.; Reyes-Díaz, M. L.; Maestre, M. V.; Cabrera, A. M.; Jimenez-Rodríguez, R. M.; Vázquez-Monchul, J. M.; Diaz-Pavón, J. M.; Padillo-Ruiz, F. J. (2017-07-29). "Treatment of transsphincteric fistula-in-ano with growth factors from autologous platelets: results of a phase II clinical trial". International Journal of Colorectal Disease. 32 (11): 1545–1550. doi:10.1007/s00384-017-2866-9. ISSN 1432-1262. PMID 28755243. S2CID 23285036.
- ^ Cite error: The named reference
Alves Grimalt 2017 pp. 18–24
was invoked but never defined (see the help page). - ^ Cite error: The named reference
prpbioactive
was invoked but never defined (see the help page). - ^ Lang, Siegmund; Loibl, Markus; Herrmann, Marietta (2018). "Platelet-Rich Plasma in Tissue Engineering: Hype and Hope". European Surgical Research. 59 (3–4): 265–275. doi:10.1159/000492415. ISSN 1421-9921. PMID 30244245. S2CID 52344177.
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Platelet-Rich Plasma Update: Clinical Use in Musculoskeletal Care
The therapy has seen increased demand from the general patient population
CHRISTOPHER ALLAN WEBB,
J Musculoskel Med. 2012;29:96-101
ABSTRACT: -
Press Release:
Platelet-rich plasma therapy a safe option for cartilage damage, new study finds
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The Positive Effects of Different Platelet-Rich Plasma Methods on Human Muscle, Bone, and Tendon Cells
Augustus D. Mazzocca,
Am J Sports Med July 16, 2012
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The Biomechanical and Histologic Effects of Platelet-Rich Plasma on Rat Rotator Cuff Repairs
Jennifer Beck et al
Am J Sports Med July 19, 2012
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Platelet-rich plasma injections for tendinopathy and osteoarthritis
Isabel Andia & Michele Abate
International Journal of Clinical Rheumatology August 2012, Vol. 7, No. 4, Pages 397-412 ,
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PLATELET RICH PLASMA FOR CHRONIC TENDINOPATHY
K Harmon, J Drezner, and A Rao
2nd International Scientific Tendinopathy Symposium; Vancouver Sept 27-29 2012
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The Systemic Effects of Platelet-Rich Plasma Injection
Amy S. Wasterlain, Hillary J. Braun, Alex H.S. Harris, Hyeon-Joo Kim and Jason L. Dragoo
Am J Sports Med December 4, 2012
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Press release:
Platelet-rich plasma treatment shows potential for knee osteoarthritis
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Platelet-rich plasma application to treat chronic tendinopathies: A review
Kaux, Jean-François and Crielaard, Jean-Michel
Acta Orthopaedica Belgica Feb-2013
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The role of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in orthopaedic bone repair and regeneration.
Friedlaender GE, Lin S, Solchaga LA, Snel LB, Lynch SE.
Curr Pharm Des. 2013 Feb 11.
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Platelet-rich plasma application in the management of chronic tendinopathies.
Kaux JF, Crielaard JM.
Acta Orthop Belg. 2013 Feb;79(1):10-5. -
Outcomes and Quality of Life after Platelet-rich Plasma Therapy in Patients with Recalcitrant Hindfoot and Ankle Diseases: A Preliminary Report of 12 Patients
Chayanin Angthong, MD, Anuwat Khadsongkram, MD, Wirana Angthong, MD
Journal of Foot and Ankle Surgery; Article in Press
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I had a letter from an orthopod who referred a patient to me regarding plantar heel pain yesterday and unusually he cited "There is no level 1 evidence for the indication and use of PRP therapy in this patient". The only thought that went through my head was "Since when has that ever stopped you before...." I must be getting old and cynical in my old age!
Be aware - orthopods are now actually reading research! ;) -
Exercise and the platelet activator calcium chloride both influence the growth factor content of platelet-rich plasma (PRP): overlooked biochemical factors that could influence PRP treatment
Bruce Hamilton, Johannes L Tol, Wade Knez, Hakim Chalabi
Br J Sports Med doi:10.1136/bjsports-2012-091916
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Platelet-rich plasma application in the management of chronic tendinopathies.
Kaux JF, Crielaard JM.
Acta Orthop Belg. 2013 Feb;79(1):10-5.
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Platelet-Rich Plasma Injections in the Treatment of Chronic Rotator Cuff Tendinopathy: A Randomized Controlled Trial With 1-Year Follow-up.
Kesikburun S, Tan AK, Yilmaz B, Yasar E, Yazicioglu K.
Am J Sports Med. 2013
QUOTE]
BACKGROUND:Rotator cuff tendinopathy (RCT) is a significant source of disability and loss of work. Platelet-rich plasma (PRP) has been suggested to be beneficial in the treatment of RCT.
PURPOSE:To investigate the effect of PRP injections on pain and shoulder functions in patients with chronic RCT.
STUDY DESIGN:Randomized controlled trial; Level of evidence, 1.
METHODS:A total of 40 patients, 18 to 70 years of age, with (1) a history of shoulder pain for >3 months during overhead-throwing activities, (2) MRI findings of RCT or partial tendon ruptures, and (3) a minimum 50% reduction in shoulder pain with subacromial injections of an anesthetic were included in this placebo-controlled, double-blind randomized clinical trial. Patients were randomized into a PRP group (n = 20) or placebo group (n = 20). Patients received an ultrasound-guided injection into the subacromial space that contained either 5 mL of PRP prepared from autologous venous blood or 5 mL of saline solution. All patients underwent a 6-week standard exercise program. Outcome measures (Western Ontario Rotator Cuff Index [WORC], Shoulder Pain and Disability Index [SPADI], 100-mm visual analog scale [VAS] of shoulder pain with the Neer test, and shoulder range of motion) were assessed at baseline and at 3, 6, 12, and 24 weeks and 1 year after injection.
RESULTS:Comparison of the patients revealed no significant difference between the groups in WORC, SPADI, and VAS scores at 1-year follow-up (P = .174, P = .314, and P = .904, respectively). Similar results were found at other assessment points. Within each group, the WORC, SPADI, and VAS scores showed significant improvements compared with baseline at all time points (P < .001). In the range of motion measures, there were no significant group × time interactions.
CONCLUSION:At 1-year follow-up, a PRP injection was found to be no more effective in improving quality of life, pain, disability, and shoulder range of motion than placebo in patients with chronic RCT who were treated with an exercise program.[/QUOTE][/QUOTE][/QUOTE] -
Is one injection such as in the study above really the standard of care? I can't recall any of my patients who have had PRP from people in Sydney ever reporting only having one injection.
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Platelet-rich plasma for foot and ankle pathologies: a systematic review
F. Vannini, B. Di Matteo, G. Filardo, E. Kon, M. Marcacci, S. Giannini
Foot and Ankle Surgery; Available online 16 August 2013
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Vijay D. Shetty, Chintan Hegde, Prajyot Jagtap, Suvin Shetty
Foot and Ankle Surgery; Available online 16 August 2013
One might see how once could become just a little confused with the amount of wibble wobble literature floating around on this subject! -
Vijay D. Shetty, Chintan Hegde, Prajyot Jagtap, Suvin Shetty
Foot and Ankle Surgery; Available online 16 August 2013
Which showed there may indeed be some indications for PRP in recalcitrant heel pain!!!
One might see how once could become just a little confused with the amount of wibble wobble literature floating around on this subject! -
Press Release:
PRP Therapy Improves Degenerative Tendon Disease in Athletes
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The use of platelet-rich plasma in the nonsurgical management of sports injuries: hype or hope?
Kimberly G. Harmon and Ashwin L. Rao
ASH Education Book December 6, 2013 vol. 2013 no. 1 620-626
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Press Release:
First the Hype, Now the Science: Evidence-based Recommendations for PRP
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Intratendinous Injection of Platelet-Rich Plasma under US Guidance to Treat Tendinopathy: A Long-Term Pilot Study
Benjamin Dallaudière et al
Journal of Vascular and Interventional Radiology; Available online 20 March 2014 -
Evidence based medicine - Tendon and platelet-rich plasma (PRP)
Kaux, Jean-François
Annual Congress RSBPRM; 5-6th December 2014
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The Effect of Autologous Platelet Rich Plasma in the Treatment of Achilles Tendon Ruptures
An Experimental Study on Rabbits
Baran Şen et al
Orthopaedic Journal of Sports Medicine November 2014 vol. 2 no. 3
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Platelet-Rich Plasma in the Treatment of Patellar Tendinopathy
A Systematic Review
Alexander D. Liddle, BSc, MRCS and E. Carlos Rodríguez-Merchán, MD, PhD
Am J Sports Med December 18, 2014
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Can platelet-rich plasma have a role in Achilles tendon surgical repair?
Angelo De Carli, Riccardo Maria Lanzetti, Alessandro Ciompi, Domenico Lupariello, Antonio Vadalà, Giuseppe Argento, Andrea Ferretti, M. C. Vulpiani, M. Vetrano
Knee Surgery, Sports Traumatology, Arthroscopy; March 2015
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I had a PRP injection for a chronic adductor enthesopathy (6/12 duration). No amount of physio / rehab helped. One PRP without local straight into the problematic area and now pain free.
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Platelet-rich plasma for muscle injuries: game over or time out?
Mosca MJ1, Rodeo SA.
Curr Rev Musculoskelet Med. 2015 Feb 27
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Does platelet-rich plasma deserve a role in the treatment of tendinopathy?
Geoffroy Nourissat, Paul Ornetti, Francis Berenbaum, Jérémie Sellame, Pascal Richette, Xavier Chevalier
Joint Bone Spine; 13 April 2015
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Platelet-rich plasma in the treatment of skeletal muscle injuries
Isabel Andia, and Michele Abate
Expert Opinion on Biological Therapy; 20 aPRIL 2105
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Double-blind, Randomized, Placebo-controlled Study Evaluating the Use of Platelet-rich Plasma Therapy (PRP) for Acute Ankle Sprains in the Emergency Department
Adam Rowden et al
The Journal of Emergency Medicine Available online 3 June 2015
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