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Platelet Rich Plasma for Musculoskeletal Conditions

Discussion in 'Biomechanics, Sports and Foot orthoses' started by NewsBot, Jan 23, 2012.

  1. NewsBot

    NewsBot The Admin that posts the news.

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    The Role of Platelet-Rich Plasma in Inducing Musculoskeletal Tissue Healing
    Brian C. Halpern, Salma Chaudhury and Scott A. Rodeo
    HSS Journal; DOI: 10.1007/s11420-011-9239-7
     
  2. Admin2

    Admin2 Administrator Staff Member

    Last edited by a moderator: May 8, 2012
  3. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Efficacy of Autologous Platelet-Rich Plasma Use for Orthopaedic Indications: A Meta-Analysis
    Ujash Sheth, BHSc; Nicole Simunovic, MSc; Guy Klein, DO; Freddie Fu, MD; Thomas A. Einhorn, MD; Emil Schemitsch, MD; Olufemi R. Ayeni, MD; Mohit Bhandari, MD, PhD
    The Journal of Bone & Joint Surgery. 2012; 94:298-307 doi:10.2106/JBJS.K.00154
     
  4. NewsBot

    NewsBot The Admin that posts the news.

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    Platelet-Rich Plasma Differs According to Preparation Method and Human Variability
    Augustus D. Mazzocca, MS, MD; Mary Beth R. McCarthy, BS; David M. Chowaniec, BS; Mark P. Cote, DPT; Anthony A. Romeo, MD; James P. Bradley, MD; Robert A. Arciero, MD; Knut Beitzel, MD
    The Journal of Bone & Joint Surgery. 2012; 94:308-316 doi:10.2106/JBJS.K.00430
     
  5. anDRe

    anDRe Active Member

  6. NewsBot

    NewsBot The Admin that posts the news.

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    Patellar Tendon Healing With Platelet-Rich Plasma: A Prospective Randomized Controlled Trial
    Adriano Marques de Almeida et al
    Am J Sports Med April 2, 2012

     
  7. NewsBot

    NewsBot The Admin that posts the news.

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    Platelet-rich plasma

    Platelet-rich plasma (PRP) is a concentrate of platelet-rich plasma protein derived from whole blood, centrifuged to remove red blood cells. It has a greater concentration of growth factors than whole blood, and has been used to encourage a brisk healing response across several specialties, in particular plastic surgery, dentistry, orthopedics and dermatology.

    As a concentrated source of blood plasma and autologous conditioned plasma, PRP contains several different growth factors and other cytokines that can stimulate healing of soft tissue and joints. There are many indications as in sports medicine and orthopedics (acute muscle strains, tendinopathy and muscle-fascial injuries and osteoarthritis[1]), or dermatology (androgenic alopecia, wound healing, and skin rejuvenation) or even in proctology (fistula-in-ano[2]). For preparation of PRP, various protocols are used, with an underlying principle of concentrating platelets to 3–5 times physiological levels, then injecting this concentrate in the tissue where healing is desired.[3]

    1. ^ Smith, Patrick A. (2016-04-01). "Intra-articular Autologous Conditioned Plasma Injections Provide Safe and Efficacious Treatment for Knee Osteoarthritis: An FDA-Sanctioned, Randomized, Double-blind, Placebo-controlled Clinical Trial". The American Journal of Sports Medicine. 44 (4): 884–891. doi:10.1177/0363546515624678. ISSN 1552-3365. PMID 26831629. 
    2. ^ de la Portilla, F.; Segura-Sampedro, J. J.; Reyes-Díaz, M. L.; Maestre, M. V.; Cabrera, A. M.; Jimenez-Rodríguez, R. M.; Vázquez-Monchul, J. M.; Diaz-Pavón, J. M.; Padillo-Ruiz, F. J. (2017-07-29). "Treatment of transsphincteric fistula-in-ano with growth factors from autologous platelets: results of a phase II clinical trial". International Journal of Colorectal Disease. doi:10.1007/s00384-017-2866-9. ISSN 1432-1262. PMID 28755243. 
    3. ^ "PRP Therapy | Hair Loss Treatment". OC Hair Restoration. Orange County, California. Retrieved 5 July 2016. 
     
  8. NewsBot

    NewsBot The Admin that posts the news.

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    Platelet-Rich Plasma Update: Clinical Use in Musculoskeletal Care
    The therapy has seen increased demand from the general patient population
    CHRISTOPHER ALLAN WEBB,
    J Musculoskel Med. 2012;29:96-101
    ABSTRACT:
     
  9. NewsBot

    NewsBot The Admin that posts the news.

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    Press Release:
    Platelet-rich plasma therapy a safe option for cartilage damage, new study finds
     
  10. NewsBot

    NewsBot The Admin that posts the news.

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    The Positive Effects of Different Platelet-Rich Plasma Methods on Human Muscle, Bone, and Tendon Cells
    Augustus D. Mazzocca,
    Am J Sports Med July 16, 2012
     
  11. NewsBot

    NewsBot The Admin that posts the news.

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    The Biomechanical and Histologic Effects of Platelet-Rich Plasma on Rat Rotator Cuff Repairs
    Jennifer Beck et al
    Am J Sports Med July 19, 2012

     
  12. NewsBot

    NewsBot The Admin that posts the news.

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    Platelet-rich plasma injections for tendinopathy and osteoarthritis
    Isabel Andia & Michele Abate
    International Journal of Clinical Rheumatology August 2012, Vol. 7, No. 4, Pages 397-412 ,
     
  13. NewsBot

    NewsBot The Admin that posts the news.

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    PLATELET RICH PLASMA FOR CHRONIC TENDINOPATHY
    K Harmon, J Drezner, and A Rao
    2nd International Scientific Tendinopathy Symposium; Vancouver Sept 27-29 2012
     
  14. NewsBot

    NewsBot The Admin that posts the news.

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    The Systemic Effects of Platelet-Rich Plasma Injection
    Amy S. Wasterlain, Hillary J. Braun, Alex H.S. Harris, Hyeon-Joo Kim and Jason L. Dragoo
    Am J Sports Med December 4, 2012
     
  15. NewsBot

    NewsBot The Admin that posts the news.

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    Press release:
    Platelet-rich plasma treatment shows potential for knee osteoarthritis
     
  16. NewsBot

    NewsBot The Admin that posts the news.

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    Platelet-rich plasma application to treat chronic tendinopathies: A review
    Kaux, Jean-François and Crielaard, Jean-Michel
    Acta Orthopaedica Belgica Feb-2013
     
  17. NewsBot

    NewsBot The Admin that posts the news.

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    The role of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in orthopaedic bone repair and regeneration.
    Friedlaender GE, Lin S, Solchaga LA, Snel LB, Lynch SE.
    Curr Pharm Des. 2013 Feb 11.
     
  18. NewsBot

    NewsBot The Admin that posts the news.

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    Platelet-rich plasma application in the management of chronic tendinopathies.
    Kaux JF, Crielaard JM.
    Acta Orthop Belg. 2013 Feb;79(1):10-5.
     
  19. NewsBot

    NewsBot The Admin that posts the news.

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    Outcomes and Quality of Life after Platelet-rich Plasma Therapy in Patients with Recalcitrant Hindfoot and Ankle Diseases: A Preliminary Report of 12 Patients
    Chayanin Angthong, MD, Anuwat Khadsongkram, MD, Wirana Angthong, MD
    Journal of Foot and Ankle Surgery; Article in Press
     
  20. Paul Bowles

    Paul Bowles Well-Known Member

    I had a letter from an orthopod who referred a patient to me regarding plantar heel pain yesterday and unusually he cited "There is no level 1 evidence for the indication and use of PRP therapy in this patient". The only thought that went through my head was "Since when has that ever stopped you before...." I must be getting old and cynical in my old age!

    Be aware - orthopods are now actually reading research! ;)
     
  21. NewsBot

    NewsBot The Admin that posts the news.

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    Exercise and the platelet activator calcium chloride both influence the growth factor content of platelet-rich plasma (PRP): overlooked biochemical factors that could influence PRP treatment
    Bruce Hamilton, Johannes L Tol, Wade Knez, Hakim Chalabi
    Br J Sports Med doi:10.1136/bjsports-2012-091916
     
  22. NewsBot

    NewsBot The Admin that posts the news.

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    Platelet-rich plasma application in the management of chronic tendinopathies.
    Kaux JF, Crielaard JM.
    Acta Orthop Belg. 2013 Feb;79(1):10-5.
     
  23. NewsBot

    NewsBot The Admin that posts the news.

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    Platelet-Rich Plasma Injections in the Treatment of Chronic Rotator Cuff Tendinopathy: A Randomized Controlled Trial With 1-Year Follow-up.
    Kesikburun S, Tan AK, Yilmaz B, Yasar E, Yazicioglu K.
    Am J Sports Med. 2013
    QUOTE]
    BACKGROUND:Rotator cuff tendinopathy (RCT) is a significant source of disability and loss of work. Platelet-rich plasma (PRP) has been suggested to be beneficial in the treatment of RCT.

    PURPOSE:To investigate the effect of PRP injections on pain and shoulder functions in patients with chronic RCT.

    STUDY DESIGN:Randomized controlled trial; Level of evidence, 1.

    METHODS:A total of 40 patients, 18 to 70 years of age, with (1) a history of shoulder pain for >3 months during overhead-throwing activities, (2) MRI findings of RCT or partial tendon ruptures, and (3) a minimum 50% reduction in shoulder pain with subacromial injections of an anesthetic were included in this placebo-controlled, double-blind randomized clinical trial. Patients were randomized into a PRP group (n = 20) or placebo group (n = 20). Patients received an ultrasound-guided injection into the subacromial space that contained either 5 mL of PRP prepared from autologous venous blood or 5 mL of saline solution. All patients underwent a 6-week standard exercise program. Outcome measures (Western Ontario Rotator Cuff Index [WORC], Shoulder Pain and Disability Index [SPADI], 100-mm visual analog scale [VAS] of shoulder pain with the Neer test, and shoulder range of motion) were assessed at baseline and at 3, 6, 12, and 24 weeks and 1 year after injection.

    RESULTS:Comparison of the patients revealed no significant difference between the groups in WORC, SPADI, and VAS scores at 1-year follow-up (P = .174, P = .314, and P = .904, respectively). Similar results were found at other assessment points. Within each group, the WORC, SPADI, and VAS scores showed significant improvements compared with baseline at all time points (P < .001). In the range of motion measures, there were no significant group × time interactions.

    CONCLUSION:At 1-year follow-up, a PRP injection was found to be no more effective in improving quality of life, pain, disability, and shoulder range of motion than placebo in patients with chronic RCT who were treated with an exercise program.[/QUOTE][/QUOTE][/QUOTE]
     
  24. Paul Bowles

    Paul Bowles Well-Known Member

    Is one injection such as in the study above really the standard of care? I can't recall any of my patients who have had PRP from people in Sydney ever reporting only having one injection.
     
  25. NewsBot

    NewsBot The Admin that posts the news.

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    Platelet-rich plasma for foot and ankle pathologies: a systematic review
    F. Vannini, B. Di Matteo, G. Filardo, E. Kon, M. Marcacci, S. Giannini
    Foot and Ankle Surgery; Available online 16 August 2013
     
  26. Paul Bowles

    Paul Bowles Well-Known Member

    A study to compare the efficacy of corticosteroid therapy with platelet-rich plasma therapy in recalcitrant plantar fasciitis: A preliminary report
    Vijay D. Shetty, Chintan Hegde, Prajyot Jagtap, Suvin Shetty
    Foot and Ankle Surgery; Available online 16 August 2013


    One might see how once could become just a little confused with the amount of wibble wobble literature floating around on this subject!
     
  27. Paul Bowles

    Paul Bowles Well-Known Member

    A study to compare the efficacy of corticosteroid therapy with platelet-rich plasma therapy in recalcitrant plantar fasciitis: A preliminary report
    Vijay D. Shetty, Chintan Hegde, Prajyot Jagtap, Suvin Shetty
    Foot and Ankle Surgery; Available online 16 August 2013

    Which showed there may indeed be some indications for PRP in recalcitrant heel pain!!!


    One might see how once could become just a little confused with the amount of wibble wobble literature floating around on this subject!
     
  28. NewsBot

    NewsBot The Admin that posts the news.

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    Press Release:
    PRP Therapy Improves Degenerative Tendon Disease in Athletes
     
  29. NewsBot

    NewsBot The Admin that posts the news.

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    The use of platelet-rich plasma in the nonsurgical management of sports injuries: hype or hope?
    Kimberly G. Harmon and Ashwin L. Rao
    ASH Education Book December 6, 2013 vol. 2013 no. 1 620-626
     
  30. NewsBot

    NewsBot The Admin that posts the news.

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    Press Release:
    First the Hype, Now the Science: Evidence-based Recommendations for PRP
     
  31. NewsBot

    NewsBot The Admin that posts the news.

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    Intratendinous Injection of Platelet-Rich Plasma under US Guidance to Treat Tendinopathy: A Long-Term Pilot Study
    Benjamin Dallaudière et al
    Journal of Vascular and Interventional Radiology; Available online 20 March 2014
     
  32. NewsBot

    NewsBot The Admin that posts the news.

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    Evidence based medicine - Tendon and platelet-rich plasma (PRP)
    Kaux, Jean-François
    Annual Congress RSBPRM; 5-6th December 2014
     
  33. NewsBot

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    The Effect of Autologous Platelet Rich Plasma in the Treatment of Achilles Tendon Ruptures
    An Experimental Study on Rabbits

    Baran Şen et al
    Orthopaedic Journal of Sports Medicine November 2014 vol. 2 no. 3
     
  34. NewsBot

    NewsBot The Admin that posts the news.

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    Platelet-Rich Plasma in the Treatment of Patellar Tendinopathy
    A Systematic Review

    Alexander D. Liddle, BSc, MRCS and E. Carlos Rodríguez-Merchán, MD, PhD
    Am J Sports Med December 18, 2014
     
  35. NewsBot

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    Can platelet-rich plasma have a role in Achilles tendon surgical repair?
    Angelo De Carli, Riccardo Maria Lanzetti, Alessandro Ciompi, Domenico Lupariello, Antonio Vadalà, Giuseppe Argento, Andrea Ferretti, M. C. Vulpiani, M. Vetrano
    Knee Surgery, Sports Traumatology, Arthroscopy; March 2015
     
  36. Tim Foran

    Tim Foran Active Member

    I had a PRP injection for a chronic adductor enthesopathy (6/12 duration). No amount of physio / rehab helped. One PRP without local straight into the problematic area and now pain free.
     
  37. NewsBot

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    Platelet-rich plasma for muscle injuries: game over or time out?
    Mosca MJ1, Rodeo SA.
    Curr Rev Musculoskelet Med. 2015 Feb 27
     
  38. NewsBot

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    Does platelet-rich plasma deserve a role in the treatment of tendinopathy?
    Geoffroy Nourissat, Paul Ornetti, Francis Berenbaum, Jérémie Sellame, Pascal Richette, Xavier Chevalier
    Joint Bone Spine; 13 April 2015
     
  39. NewsBot

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    Platelet-rich plasma in the treatment of skeletal muscle injuries
    Isabel Andia, and Michele Abate
    Expert Opinion on Biological Therapy; 20 aPRIL 2105
     
  40. NewsBot

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    Double-blind, Randomized, Placebo-controlled Study Evaluating the Use of Platelet-rich Plasma Therapy (PRP) for Acute Ankle Sprains in the Emergency Department
    Adam Rowden et al
    The Journal of Emergency Medicine Available online 3 June 2015
     
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