Risk factors for diabetes amputation

NewsBot · Nov 6, 2024

The Risk of and Associated Demographic and Laboratory Variables for Amputations for Inpatients with Diabetic Foot Ulcers
Shiming Xu, et al
Source

Diabetic foot ulcers (DFUs) are a leading cause of morbidity and mortality, which disproportionately impacts underserved populations. This study aimed to provide data regarding the rates and outcomes of amputation in patients admitted with DFU in our health system, which cares for an ethnically diverse and underserved population.
Methods
This retrospective study examined the electronic medical records of adult patients hospitalized with DFU at 3 hospitals in our health system between June 1, 2016, and May 31, 2021.
Results
Among 650 patients admitted with DFU, 88% self-identified as non-White race. Male sex (odds ratio [OR], 0.62), low body mass index (OR, 0.98), and history of smoking (OR, 1.45) were significantly associated with amputation during the study period. A higher erythrocyte sedimentation rate (OR, 1.01), C-reactive protein level (OR, 1.05), and white blood cell count (OR, 1.11) and low albumin level (OR, 0.41) were found to be significantly associated with amputation versus no amputation during admission. The amputation risk during the index admission for DFU was 44%.
Conclusion
Our study identified a high DFU-related amputation risk (44%) among adult patients who were mostly Black and/or Hispanic. The significant risk factors associated with DFU amputation included male sex, low body mass index, smoking, and high levels inflammation or low levels of albumin during admission. Many of these patients required multidisciplinary care and intravenous antibiotic therapy, necessitating a longer length of stay and high readmission rate.
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NewsBot · Nov 10, 2024

Risk Factors Associated with Amputation for
Patients with Diabetic Foot Ulcers:
A Retrospective Study
Bo Yang et al
Source

Objective: Diabetic foot ulcer (DFU) and related amputation significantly contribute to morbidity rates. The objective of this study
was to assess the risk factors correlated with amputation in Chinese patients with DFU.
Methods: A prospective study was implemented on DFU patients at Third Affiliated Hospital of Anhui Medical University from
February 2016 to May 2024. Patients were categorized into two groups based on whether they underwent amputation: the amputation
group (n = 33) and the non-amputation group (n = 29). A comparative analysis was conducted between two groups, focusing on
demographic data, disease characteristics, and laboratory indicators. Binary and multivariate logistic regressions were employed to
evaluate the risk factors associated with amputation. Receiver Operating Characteristic curve analysis was used to assess the risk
factors in predicting amputation in patients with DFU.
Results: The incidence of history of amputation, duration of diabetes in the amputation group were significantly increased compared
to the non-amputation group (P < 0.05). On the contrary, the red blood cell count, hemoglobin level, and hematocrit in the amputation
group were significantly lower compared to the non-amputation group (P < 0.05). Moreover, in the bi-variable logistic regression
analysis, the duration of diabetes, duration of DFU, history of amputation, and hemoglobin levels were significantly associated with
amputation (P < 0.05). After controlling potential confounding factors in multiple logistic regression analysis, duration of DFU was
identified as a determining factor for amputation (P < 0.05). Additionally, the values for the area under curve (AUC) in relation to the
duration of diabetes, duration of DFU, history of amputation, and a combined panel in predicting the occurrence of amputation in
patients with DFU were 0.890, 0.868, 0.730, and 0.916, respectively.
Conclusion: Our findings indicate that duration of DFU is an independent risk factor for amputation in patients with DFU.
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NewsBot · Nov 13, 2024

Risk Factors Associated with Amputation for Patients with Diabetic Foot Ulcers: A Retrospective Study
Bo Yang et al
Diabetes Metab Syndr Obes. 2024 Nov 7:17:4201-4209

Objective: Diabetic foot ulcer (DFU) and related amputation significantly contribute to morbidity rates. The objective of this study was to assess the risk factors correlated with amputation in Chinese patients with DFU.

Methods: A prospective study was implemented on DFU patients at Third Affiliated Hospital of Anhui Medical University from February 2016 to May 2024. Patients were categorized into two groups based on whether they underwent amputation: the amputation group (n = 33) and the non-amputation group (n = 29). A comparative analysis was conducted between two groups, focusing on demographic data, disease characteristics, and laboratory indicators. Binary and multivariate logistic regressions were employed to evaluate the risk factors associated with amputation. Receiver Operating Characteristic curve analysis was used to assess the risk factors in predicting amputation in patients with DFU.

Results: The incidence of history of amputation, duration of diabetes in the amputation group were significantly increased compared to the non-amputation group (P < 0.05). On the contrary, the red blood cell count, hemoglobin level, and hematocrit in the amputation group were significantly lower compared to the non-amputation group (P < 0.05). Moreover, in the bi-variable logistic regression analysis, the duration of diabetes, duration of DFU, history of amputation, and hemoglobin levels were significantly associated with amputation (P < 0.05). After controlling potential confounding factors in multiple logistic regression analysis, duration of DFU was identified as a determining factor for amputation (P < 0.05). Additionally, the values for the area under curve (AUC) in relation to the duration of diabetes, duration of DFU, history of amputation, and a combined panel in predicting the occurrence of amputation in patients with DFU were 0.890, 0.868, 0.730, and 0.916, respectively.

Conclusion: Our findings indicate that duration of DFU is an independent risk factor for amputation in patients with DFU.
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NewsBot · Nov 15, 2024

Analysis of clinical characteristics in patients with diabetic foot ulcers undergoing amputation and establishment of a nomogram prediction model
Tiantian Xu et al
Sci Rep. 2024 Nov 14;14(1):27934

To assess the accuracy of a nomogram for predicting the risk of lower-extremity amputation (LEA) in individuals with diabetic foot ulcers (DFUs). We retrospectively analyzed data from 144 patients with DFUs at the Department of Orthopedics of the First Affiliated Hospital of Nanchang University, collected between January 2020 and December 2023. Univariate analysis determined primary predictive factors for amputation, followed by single and multifactor logistic regression analyses to indentify independent factors. These were utilized to develop a prediction model using R4.3.3, and a nomogram was created. Its performance was verified using receiver operating characteristic (ROC), corrected calibration, and clinical decision curves. Twelve primary predictive factors were identified from 20 variables, including age, Wagner grades, peripheral angiopathy of diabetes (PAD), chronic kidney disease(CKD), C-reactive protein(CRP) and the number of blood sugar abnormalities(BSA) etc. Multivariate logical regression analysis illustrated that Wagner grades, PAD, CRP, CKD, and the number of BSA were independent risk factors. The area under the curve (AUC) of the ROC curve was 0.967, and the revised calibration curve of the nomogram demonstrated strong fitting ability. This prediction model is a valuable tool for screening LEA risk and preventing DFU from progressing into amputation.
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NewsBot · Dec 7, 2024 at 11:16 PM

Risk Factors for Lower Extremity Amputation among Diabetic Patients with Diabetic Foot Gangrene in ATBUTH, Bauchi
Stephen Yusuf et al
Open Journal of Orthopedics > Vol.14 No.9, September 2024

Background: Diabetic mellitus was described as an evolving global epidemic of the twenty-first century, due to the exponential rise in the number of people with the condition. Lower extremity amputation is one of the common complications of diabetes. With increase in the number of people with diabetes there will also be increase in the number of diabetics going for lower extremity amputation, increasing both the financial as well as psychologic burden of treatment. Methodology: A prospective cross-sectional study of all diabetic patients going for lower extremity amputation will be done. All the patients with advanced diabetic foot syndrome needing lower extremity amputation are enrolled (Wagener stage IV and V), both through the clinic and emergency center. Informed consent is obtained from the patient after which data are collected using a structured questionnaire. All the investigation results of the patients were also documented. Data collected are analyzed using the SPSS version 29. Chi-square and student t-test were used to measure significant relationship between the variables at 95% confident interval. Results: Within the period of study, which extends from 1st January 2022 to 1st of January 2024, a total of 171 patients were recruited. All diabetic patients with diabetic foot Wagener grade IV and V who presented to the clinic or emergency department were enrolled in the study. We found a significant relationship between gender, previous procedure on the affected limb or amputation of the contralateral limb, knowledge of foot care among diabetics and risk of amputation. There was, however, no statistically significant relationship between. There is no statistically significance relationship between the level of education, occupation, presence of co-morbidity with the risk of amputation among diabetic patients with foot syndrome. Conclusion: Previous lower limb procedure/amputation, male gender, paucity of knowledge on foot care, prolonged duration of the disease and method of treatment are important risk factors for the risk of amputation among diabetic patients with diabetic foot syndrome.
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Risk factors for diabetes amputation

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Risk factors for diabetes amputation

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NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

Risk Factors for Fractures and Falls in Older Women with Type 2 Diabetes

Chronic diseases and allergies as risk factors for MTSS

Risk factors for ingrown toenails

Incidence and Risk Factors for Pin Site Infection of Exposed Kirschner Wires

The risk factors for diabetic peripheral neuropathy

Incidence and Risk Factors for Foot Fractures

Genetic risk factors for plantar fasciitis

Share This Page

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