Risk of gout after vaccination

NewsBot · Aug 3, 2019

Members do not see these Ads. Sign Up.
Risk of gout flares after vaccination: a prospective case cross-over study.
Yokose C et al
Ann Rheum Dis. 2019 Jul 31

OBJECTIVES:
The recombinant zoster vaccine (RZV) containing a strong non-aluminium adjuvant is associated with increased risk of gout flares, presumably via NLRP3 inflammasome activation. We tested the possibility that other vaccines may also be associated with gout flares.

METHODS:
We conducted an online case-crossover study of patients with gout to examine the association between vaccination and gout flares. We collected information through the Internet on exposures to potential risk factors, including vaccinations, during 2-day hazard periods prior to gout flare and 2-day control periods without a flare. Conditional logistic regression was used to adjust for covariates.

RESULTS:
There were 517 participants with gout (mean age 55 years, 79% male) who experienced gout flares during follow-up. There were 28 vaccinations during 990 hazard periods and 21 vaccinations during 1407 control periods. Vaccination was associated with twofold higher odds of gout flare (adjusted OR 1.99; 95% CI 1.01 to 3.89).

CONCLUSION:
Our findings suggest vaccines other than RZV are associated with increased odds of gout flares, potentially through a shared pathogenetic mechanism like NLRP3 inflammasome. However, the absolute magnitude of increased odds of gout flares with vaccinations remains small and must be interpreted within the context of the overwhelming benefits of vaccinations.
Click to expand...

NewsBot The Admin that posts the news.

Diabetes Mellitus Is Associated with a Lower Risk of Gout

Flexible Pes Planus as a Potential Risk Factor for Cardiac Pathologies

Permanent Senior Podiatrist role 4 days. High risk foot. South Sydney

1st MPJ ulcerations in high risk 'pes cavus' feet

Palliative care needs in people with or at risk of developing diabetic foot ulcers

Suicide Risk Screening in Outpatient Podiatry Patients

Influence of Cognitive Performance on Musculoskeletal Injury Risk

Share This Page