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Tagamet (cimetidine) for wart treatment

Discussion in 'General Issues and Discussion Forum' started by LCG, Mar 7, 2006.

  1. LCG

    LCG Active Member

    Members do not see these Ads. Sign Up.
    Has anyone heard of any scientific based research that advocates the use of tagamet (usually reserved for duodenal ucers) in the treatment of recalcitrent warts.
    Better still has anyone had experince in using it?
  2. Admin2

    Admin2 Administrator Staff Member


    Cimetidine as a First-Line Therapy for Pedal Verruca Eight-Year Retrospective Analysis
    J Am Podiatr Med Assoc 95(3): 229–234, 2005
    Cimetidine therapy for recalcitrant warts in adults.
    Arch Dermatol. 1996 Jun;132(6):680-2.
    Cimetidine therapy for recalcitrant warts in adults: is it any better than placebo?
    [size=-1]J Am Acad Dermatol. 1999 Jul;41(1):123-7[/size]
    Last edited by a moderator: Mar 7, 2006
  3. Dawn Bacon

    Dawn Bacon Active Member

    Dear LCG,
    I have seen cimetidine used once in this way.
    An 11 year old boy with mosaic vp covering most of both plantar surfaces whom I referred to the dermatologist. Response was both rapid and positive, and to my knowledge, there has been no recurrence (this all happened 5 years ago).

    This said, I have never understood the mechanism of how an H2 receptor antagonist helped in the treatment of vps.
  4. DrPod

    DrPod Active Member

  5. Nikki

    Nikki Active Member

    Only last Monday I had a patient come to my clinic saying the Dermatologists had suggested Cimetidine for treatment of VP's. She did say however they were a little off-hand and not very convincing about its effectiveness.
    Will pass on the above info to the lady concerned, and keep you posted regarding results.

  6. LCG

    LCG Active Member

    thanks for the feedback guys much appreciated I will keep you informed of the results
  7. R.E.G

    R.E.G Active Member

    Hi LCG and Pol


    But used it on a 20 year old micro biologist UK student in the USA with 'success', (wrote it up but did not publish, now doing PHD) and a 23 year old air hostess.

    Both had access to cheap unlimited supply.

    I am interested in Imiquimod, the Germans have done some work, but like cimetidine, not licenced so it's over to the Uni's, unless we 'workers' can get organised to do some trials.

    As a private practitioner I get very frustrated about the lack of access to 'science'.

  8. Admin2

    Admin2 Administrator Staff Member

    Earlier in this thread there was the abstract from:
    Since that publication, there have been an exchange in the letters-to-the-editor section of JAPMA about this:

    Michael Turlik. Letter to the Editor: Cimetidine as a First-Line Therapy for Pedal Verruca J Am Podiatr Med Assoc 2005 95: 508

    Barry R. Mullen, John V. Guiliana, and Fawaz Nesheiwat. Letter to the Editor: Cimetidine as a First-Line Therapy for Pedal Verruca: Authors’ Response J Am Podiatr Med Assoc 2005 95: 508-a

    Karl B. Landorf. Letter to the Editor: Cimetidine as a First-Line Therapy for Pedal Verruca. J Am Podiatr Med Assoc 2006 96: 184-185.

    (an individual or instituitional subscription is needed to access the full text of these)
  9. R.E.G

    R.E.G Active Member


    fantastic references, but useless to anyone without access.

    While I can accept you cannot 'publish' the work, how about a 'precis'. Is it worth spending the money?

  10. admin

    admin Administrator Staff Member

    They are in the mail ;)
  11. R.E.G

    R.E.G Active Member


    Thanks for that, a very interesting discussion and probably way beyond my BSc stats.

    However I have done a Google search on Cemitidine and come up with Dermatology On Line Journal Vol ( number 2.

    What a confusing picture? :(

    I am prepared to be shot down in flames, but as far as I can See a lot of the 'gold standard' trials are on very small (though statistically significant) populations.

    In a previous life I was a work study engineer, (long obsolete) knew nothing but trained to challenge 'everything'.

    What I find most interesting in any study are the 'exceptions/ failures' the extremes of the statistical analysis. There must be a reason for them?

    I have yet to see a study showing 100% resolution of a VP by a treatment,

    Can I question whether we are always asking the right question or examining the outcomes of our trials correctly? Are the 'trials' too simplistic to investigate 'complex' situations.

    Please do not crucify me I'm only a chiropodist, but like many others, (including the Bio men) we see the results but cannot prove them.


    Sorry forgot to mention the significant point about this thread 'First line treatment'.

    Certainly in the UK not an option, but what is the 'first line treatment'? Any comments
  12. John Spina

    John Spina Active Member

    Anecdotally,it is said to work and in fact,many pods have used cimetidine for stubborn warts.I have not seen much in the way of research on this.
  13. Anne McLean

    Anne McLean Active Member

    Hi All,

    Some of my patients have used Cimetidine (Tagamet) in the treatment of verrucae. This has been used in a dosage of 2 - 3 x 400mg tablets per day. Sometimes it has been used in conjunction with zinc tablets and others with the application of Glutarol.

    With lesions, which have survived for up to four years, there has been a marked improvement within 3 weeks - 3 months. I only use this treatment with female patients, due to the tendency of male patients to develop breast tissue with this medication.

    Last edited: May 24, 2006
  14. NewsBot

    NewsBot The Admin that posts the news.

    Comparison of the therapeutic efficacy of cimetidine and cryotherapy with placebo and cryotherapy in treatment of warts
    Nastaran Safavi Ardabili, Rostami Mogaddam Majid
    Journal of Pakistan Association of Dermatologists. 2014;24 (3):251-255

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