Toenail-Based Metal Concentrations and Young-Onset Breast Cancer

NewsBot · Dec 26, 2019

Members do not see these Ads. Sign Up.
Toenail-Based Metal Concentrations and Young-Onset Breast Cancer.
O'Brien KM et al
Am J Epidemiol. 2019 Apr 1;188(4)

Several metals have carcinogenic properties, but their associations with breast cancer are not established. We studied cadmium, a metalloestrogen, and 9 other metals-arsenic, cobalt, chromium, copper, mercury, molybdenum, lead, tin, and vanadium--in relation to young-onset breast cancer (diagnosis age <50 years), which tends to be more aggressive than and have a different risk profile from later-onset disease. Recent metal exposure was measured by assessing element concentrations, via inductively coupled plasma mass spectrometry, in toenail clippings of 1,217 disease-discordant sister pairs in the US-based Sister (2003-2009) and Two Sister (2008-2010) studies. Conditional logistic regression was used to calculate odds ratios and 95% confidence intervals. After correcting for differential calendar time of sample collection, no statistically significant associations were observed between any metals and breast cancer. Vanadium had the largest odds ratio (for fourth vs. first quartile, odds ratio = 1.36, 95% confidence interval: 0.84, 2.21; P for trend = 0.17). Cadmium was associated with a small increase in risk, with no evidence of a dose-response relationship (for fourth vs. first quartile, odds ratio = 1.15, 95% confidence interval: 0.82, 1.60; P for trend = 0.67). Positive associations between urinary cadmium concentrations and breast cancer have been reported in case-control studies, but we observed no such association between young-onset breast cancer and toenail concentrations of any assessed metals
Click to expand...

NewsBot · Jan 6, 2022

RETRACTION: “TOENAIL-BASED METAL CONCENTRATIONS AND YOUNG-ONSET BREAST CANCER”
American Journal of Epidemiology, Volume 189, Issue 1, January 2020, Page 79, https://doi.org/10.1093/aje/kwz235

After publication of our article “Toenail-Based Metal Concentrations and Young-Onset Breast Cancer” (1), we noticed that we had made a programming error when we merged the toenail metal measurements with the other covariates. This resulted in many individuals being assigned incorrect values for their metal concentrations. After correcting the error, we re-ran all statistical models and found differences in the reported estimates, as well as a reduction in the sample size due to missing data from members of matched pair sets (original n = 1,217; new n = 1,214).

Despite these differences, our finding of “no statistically significant associations between any metals and breast cancer” was unchanged, but because all reported effect estimates changed somewhat, we have decided to issue a retraction of our article. We apologize for this error.
Click to expand...

NewsBot · Jan 6, 2022

Metals and Breast Cancer Risk: A Prospective Study Using Toenail Biomarkers
Nicole M Niehoff, Katie M O’Brien, Alexander P Keil, Keith E Levine, Chamindu Liyanapatirana, Laura G Haines, Suramya Waidyanatha, Clarice R Weinberg, Alexandra J White
American Journal of Epidemiology, Volume 190, Issue 11, November 2021, Pages 2360–2373

The role of metals in breast cancer is of interest because of their carcinogenic and endocrine-disrupting capabilities. Evidence from epidemiologic studies remains elusive, and prior studies have not investigated metal mixtures. In a case cohort nested within the Sister Study (enrolled in 2003–2009; followed through September 2017), we measured concentrations of 15 metals in toenails collected at enrollment in a race/ethnicity-stratified sample of 1,495 cases and a subcohort of 1,605 women. We estimated hazard ratios and 95% confidence intervals for each metal using Cox regression and robust variance. We used quantile g-computation to estimate the joint association between multiple metals and breast cancer risk. The average duration of follow-up was 7.5 years. There was little evidence supporting an association between individual metals and breast cancer. An exception was molybdenum, which was associated with reduced incidence of overall breast cancer risk (third tertile vs. first tertile: hazard ratio = 0.82, 95% confidence interval: 0.67, 1.00). An inverse association for antimony was observed among non-Hispanic Black women. Predefined groups of metals (all metals, nonessential metals, essential metals, and metalloestrogens) were not strongly associated with breast cancer. This study offers little support for metals, individually or as mixtures, as risk factors for breast cancer. Mechanisms for inverse associations with some metals warrant further study.
Click to expand...

Toenail-Based Metal Concentrations and Young-Onset Breast Cancer

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

Topical Therapy for Toenail Onychomycosis: An Evidence-Based Review

Ultrasound clinical references of the healthy toenail unit

Extreme pain after toenail removal--normal?

Injection therapy for ingrown toenails

Toenail Dust as a Potential Occupational Hazard in Podiatric Medicine

Spiculectomy and Orthonyxia for Ingrown Toenails

Self-Administered Treatment Kit for Ingrowing Toenail

Share This Page

Toenail-Based Metal Concentrations and Young-Onset Breast Cancer

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

Topical Therapy for Toenail Onychomycosis: An Evidence-Based Review

Ultrasound clinical references of the healthy toenail unit

Extreme pain after toenail removal--normal?

Injection therapy for ingrown toenails

Toenail Dust as a Potential Occupational Hazard in Podiatric Medicine

Spiculectomy and Orthonyxia for Ingrown Toenails

Self-Administered Treatment Kit for Ingrowing Toenail

Share This Page

Useful Searches