Westmead study shows vitamin C prevents ulcer-related amputations

Cameron · Oct 22, 2020

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Passed on in good faith Source: The Pulse

https://thepulse.org.au/2020/10/21/...vitamin-c-prevents-ulcer-related-amputations/

Full study published at British Journal of Nutrition <https://www.cambridge.org/core/jour...rolled-trial/B862F414BE336B09FC405A3510EBD318>

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NewsBot · Oct 5, 2021

The Effect of Vitamin C Administration on Contrast-Induced Nephropathy in Diabetic Foot Ulcer Patients Performing Digital Subtraction Angiography.
Aulia Thabrani, Darmawan Ismail, Ida Bagus Budhi.
Annals of the Romanian Society for Cell Biology, 25(6), 20415–20421

BACKGROUND: The prevalence of diabetic foot ulcers in the world in 2016 was 6.3%. Digital Subtraction Angiography is the standard contrast angiography examination. Contrast-Induced Nephropathy is a complication of angiographic procedures. Vitamin C from various studies has a role in preventing the occurrence of Contrast-Induced Nephropathy.

AIM: The purpose of this study was to determine the effect of giving Vitamin C on the incidence of Contrast-Induced Nephropathy.

METHODS: This study used a quasi-experimental design using a two-group pretest-posttest control-group design. It was conducted in the sub-section of Cardiovascular Thoracic Surgery, dr. Moewardi General Hospital Surakarta from June to July 2021. Data were analyzed using the paired sample t-test and the related samples Wilcoxon signed-rank test.

RESULTS: The results of statistical analysis showed a p-value of < 0.05 for Group B’s creatinine and e-GFR variables. Meanwhile, for Group A’s creatinine and Group A’s e-GFR, there was no significant difference with p > 0.05. This shows that there is an incidence of CIN in Group B because there is an increase in serum creatinine and e-GFR.

CONCLUSION: Vitamin C can maintain serum creatinine and GFR in normal conditions. This indicates that vitamin C can prevent the occurrence of Contrast-Induced Nephropathy.
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NewsBot · Sep 18, 2022

Vitamin C and the management of diabetic foot ulcers: a literature review
Khanh Phuong Tong, Robert Intine, Stephanie Wu
J Wound Care. 2022 Sep 1;31(Sup9):S33-S44

Objective: The lifetime risk of developing a diabetic foot ulcer (DFU) in people with diabetes is as high as 25%. A trio of factors constitute the diabetic foot syndrome that characterises DFUs, including neuropathy, vascular disease and infections. Vitamin C has important functions in the nervous, cardiovascular, and immune systems that are implicated in DFU development. Furthermore, vitamin C deficiency has been observed in individuals with DFUs, suggesting an important function of vitamin C in DFU management and treatment. Therefore, this literature review evaluates the role of vitamin C in the nervous, cardiovascular and immune systems in relation to wound healing and DFUs, as well as discussing vitamin C's lesser known role in depression, a condition that affects many individuals with a DFU.

Method: A literature search was done using PubMed, Cochrane Library, Embase, Ovid, Computer Retrieval of Information on Scientific Projects, and NIH Clinical Center. Search terms included 'diabetic foot ulcer,' 'diabetic foot,' 'vitamin C,' and 'ascorbic acid.'

Results: Of the 71 studies initially identified, seven studies met the inclusion criteria, and only three were human clinical trials. Overall, the literature on this subject is limited, with mainly observational and animal studies, and few human clinical trials.

Conclusion: There is a need for additional human clinical trials on vitamin C supplementation in individuals with a DFU to fill the knowledge gap and guide clinical practice.
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