Autologous fat transplantation for diabetic foot ulcers

NewsBot · Mar 1, 2019

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Autologous nanofat transplantation accelerates foot wound healing in diabetic rats.
Chen L et al
Regen Med. 2019 Feb 27

AIM:
This study explored the effects of local transplantation of autologous nanofat in the treatment of rats with diabetic foot wounds.

MATERIALS & METHODS:
Nanofat was transplanted into the left foot wound of diabetic rats. Phosphate-buffered saline injection in the right served as control. We measured wound size, the extent of epithelization, microvessel density and the expression levels of cytokines at six different time-points postoperation.

RESULTS:
Compared with the control feet, nanofat-treated feet had significantly smaller wound areas at 7 and 9 days after grafting and showed better re-epithelialization, a greater number of microvessels and higher levels of angiogenic factor expression.

CONCLUSION:
This research shows that autologous nanofat transplantation can promote diabetic foot wound healing in rats.
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