The evidence documenting the role of nutrition in improving wound healing and neuropathy symptoms hasn’t been widely publicized, particularly among lower extremity healthcare practitioners. But getting that information to your diabetic patients could help save their feet. http://www.lowerextremityreview.com/article/better-nutrition-boosts-diabetic-foot-outcomes
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Related thread:
Nutritional supplements and wound healing -
Short term supplementation of dietary antioxidants selectively regulates the inflammatory responses during early cutaneous wound healing in diabetic mice.
Nutr Metab (Lond). 2011 Nov 17;8(1):80.
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Prevalence and severity of vitamin D deficiency in patients with diabetic foot infection.
Tiwari S, Pratyush DD, Gupta B, Dwivedi A, Chaudhary S, Rayicherla RK, Gupta SK, Singh SK.
Br J Nutr. 2012 Apr 3:1-4.
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A thread on "better nutrition" for diabetes management... or better still, a step further... even the reversal of the disease... even neuropathy.
One physician at the forefront of the area is Dr Neal Barnard (Wiki Link) & his research into a plant based diet & diabetes management. His website here for further info.
I have been reading & hearing about his work for a while now & I personally feel it is information that everybody should be aware of if they are responsible for treating diabetics. For example, here is a link of interest...
- Section Four: Diabetes.
With a section on neuropathy...
- Nutritional Factors in Neuropathy:
- Regression of Diabetic Neuropathy with Total Vegetarian (Vegan) Diet:
Milton G. Crane and Clyde Sample.
Mark F. McCarty.
Caroline B. Trapp and Neal D. Barnard.
Neal D Barnard1,2, Heather I Katcher2, David JA Jenkins3, Joshua Cohen1, Gabrielle Turner-McGrievy4
Last edited by a moderator: Sep 22, 2016 -
Nutrition supplementation for diabetic wound healing: a systematic review of current literature.
Maier HM, Ilich JZ, Kim JS, Spicer MT.
Skinmed. 2013 Jul-Aug;11(4):217-24
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From Podiatry today:
Remembering Nutritional Analysis In The Wound Care Patient -
I know this thread has been focussing on better nutrition relating to wound healing & neuropathy (of the "diabetic foot")... but it would also be beneficial to understand nutritional links to the incidence of Type 2 Diabetes... as the saying goes... "prevention is better than cure"... that said, cure could also be obtained through better nutritional practices:
Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-INTERACT Case-Cohort Study:
High Protein Intake Linked to Higher Type 2 Diabetes Incidence:
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Effect of oral nutritional supplementation on wound healing in diabetic foot ulcers: a prospective randomized controlled trial.
Armstrong DG, Hanft JR, Driver VR, Smith AP, Lazaro-Martinez JL, Reyzelman AM, Furst GJ, Vayser DJ, Cervantes HL, Snyder RJ, Moore MF, May PE, Nelson JL, Baggs GE, Voss AC; The Diabetic Foot Nutrition Study Group..
Diabet Med. 2014 May 28.
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This clinical trial has just been registered:
Impact of Malnutrition on the Healing of Foot Lesions in Diabetic Patients
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Vitamin D deficiency is associated with inflammatory cytokine concentrations in patients with diabetic foot infection.
Tiwari S, Pratyush DD, Gupta SK, Singh SK
The British Journal of Nutrition [2014:1-6]
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Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-α and EGF production in chronic leg wound healing.
Nasole E, Nicoletti C, Yang ZJ, Girelli A, Rubini A, Giuffreda F, Di Tano A, Camporesi E, Bosco G.
J Enzyme Inhib Med Chem. 2014 Apr;29(2):297-302.
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Multiple Biological Actions of Curcumin in the Management of Diabetic Foot
Ulcer Complications: A Systematic Review
Kuppusamy Gowthamarajan, Veera Venkata Satyanarayana Reddy Karri, Satish Kumar MN and Rajkumar Malayandi
Trop Med Surg 2015, 3:1
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The impact of nutritional status on treatment outcomes of patients with limb-threatening diabetic foot ulcers.
Gau BR et al
J Diabetes Complications. 2015 Sep 26
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Raised serum 25-hydroxyvitamin D levels in patients with active diabetic foot ulcers.
Afarideh M et al
Br J Nutr. 2016 Jun;115(11):1938-46
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Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial.Bahadoran Z1, Mirmiran P, Hosseinpanah F, Hedayati M, Hosseinpour-Niazi S, Azizi F.
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A Systematic Review and Meta-Analysis of Nutritional Supplementation in Chronic Lower Extremity Wounds
Junna Ye et al
International Journal of Lower Extremity Wounds November 3, 2016
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The effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.
Momen-Heravi M et al
Wound Repair Regen. 2017 Apr 10. doi: 10.1111/wrr.12537
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Red Meat and Poultry Tied to Increased Type 2 Diabetes Risk
Veronica Hackethal, MD
September 21, 2017
"Eating red meat or darker cuts of poultry may be associated with increased risk of type 2 diabetes, with higher levels of consumption linked to higher risk, according to new results from the Singapore Chinese Health Study, published in the American Journal of Epidemiology.
The trial is one of the largest to evaluate meat consumption and diabetes risk in Asian populations.
"Compared with those who ate the least amount, those with the highest levels (approximately one serving a day) of red meat or poultry consumption had a 23% and 15% increased risk of diabetes, respectively," lead author Woon-Puay Koh, PhD, a professor at Duke-NUS Medical School, Singapore, commented by email.
Results also suggest that different types of meat may have different effects on type 2 diabetes risk. Varying levels of heme iron, which is found only in meat, may be involved.
"After adjustment for heme-iron content in the diet, the red-meat/diabetes association was still present, suggesting that other chemicals present in red meat could be accountable for the increase in risk of diabetes," Dr Koh explained.
"Conversely, the association between poultry intake and diabetes risk went away, suggesting that this risk was attributable to the heme-iron content in poultry." The darker cuts of poultry, such as chicken thighs, have higher heme-iron content than breast meat, she noted... "- For more... see Medscape article... https://www.medscape.com/viewarticl...uac=156241CR&spon=17&impID=1442831&faf=1#vp_1
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This clinical trial was just registered:
Nutritional Supplement on Wound Healing in Diabetic Foot
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Malnutrition in type 2 diabetic patients does not affect healing of foot ulcers.
Rouland A et al
Acta Diabetol. 2018 Oct 3.
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Nutrition Supplementation and Education May Increase the Healing Rate in Diabetic Patients with Foot Ulcers
Basiri R et al
Curr Dev Nutr. 2019 Jun 13;3(Suppl 1). pii: nzz049.P19-005-19
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Amino acids and wound healing in people with limb-threatening diabetic foot ulcers☆
Shih-YuanHungabJir-ShiongTsaicJiun-TingYehbdKuan-HsingChenbeChia-NiLinfgHui-MeiYangaCheng-WeiLinaHsin-YunChenahChung-HueiHuangabYu-YaoHuangabh
Journal of Diabetes and its Complications; 6 July 2019
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Informative x 1 - List
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Ultra-Processed Foods Now Linked to Risk of Type 2 Diabetes
(Link: https://www.medscape.com/viewarticle/922702)
"High consumption of so-called ultra-processed foods is associated with an increased risk of type 2 diabetes, independent of other risk factors including weight and nutritional quality of the diet, a new study indicates. The results suggest a possible modifiable target for prevention of diabetes, say the authors.
"To our knowledge, although ultra-processed foods consumption was previously found to be associated with increased risks of cancer, cardiovascular diseases, mortality, depressive symptoms, and metabolic disorders, no prior prospective epidemiological study had evaluated their association with type 2 diabetes risk," write Bernard Srour, PharmD, MPH, PhD, and colleagues in their article published online today in JAMA Internal Medicine.
The study involved 104,707 participants in the ongoing, web-based NutriNet-Santé study in France, the majority of whom were women (79.2% vs 20.8%).
Participants, who were a mean baseline age of 42 years, provided repeated 24-hour dietary records on their consumption of more than 3500 food items. They also reported on major health events, including type 2 diabetes; the findings were further confirmed using medication reimbursement data..." -
Nutritional Intervention Improves the Dietary Intake of Essential Micronutrients in Patients with Diabetic Foot Ulcers
Raedeh Basiri, Maria Spicer, Joseph Munoz, Bahram Arjmandi
Current Developments in Nutrition, Volume 4, Issue Supplement_2, June 2020, Page 8, https://doi.org/10.1093/cdn/nzaa040_008
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Diabetic Foot Ulcers: Correlation of Nutritional Status of Type 2 Diabetic Patients of Hyderabad Sindh, Pakistan
IMRAN ALI SHAIKH SR.
Diabetes 2020 Jun; 69(Supplement 1): -.
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Are enteral nutrition solutions effective in patients with diabetic
foot wounds?
Sami Açar
Clin Sci Nutr 2020
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Nutritional interventions for treating foot ulcers in people with diabetes
Zena Eh Moore et al
Cochrane Database Syst Rev. 2020 Jul 17;7:CD011378
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Efficacy of Oral Protein Supplementation “PRO 360 Diabetic” on
Diabetic Foot Ulcer Patients-A Pilot study
Rajesh Kesavan et al
J Food Sci Nutr Res 2020; 3 (3): 195-205
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Vitamin C Improves Healing of Foot Ulcers; A Randomised, Double-Blind, Placebo-Controlled Trial
Jenny E. Gunton et al
Published online by Cambridge University Press: 28 September 2020
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Vitamin D Supplementation in Diabetic Foot Ulcers: A Current Perspective
Shilia Jacob Kurian et al
Curr Diabetes Rev. 2020 Oct 12
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The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial
Mehrdad Mokhtari et al
Phytother Res. 2020 Nov 16
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The effects of dietary/herbal supplements and the serum levels of micronutrients on the healing of diabetic foot ulcers in animal and human models: a systematic review
Mohammad Reza Amini, Maryam Aalaa, Ensieh Nasli-Esfahani, Rasha Atlasi, Mahnaz Sanjari & Nazli Namazi
Journal of Diabetes & Metabolic Disorders (2021)
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Efficacy of curcumin for wound repair in diabetic rats/mice: a systematic review and meta-analysis of preclinical studies
Yuan Li et al
Curr Pharm Des. 2021 Jun 17
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The effects of dietary/herbal supplements and the serum levels of micronutrients on the healing of diabetic foot ulcers in animal and human models: a systematic review
Mohammad Reza Amini et al
J Diabetes Metab Disord. 2021 May 26;20(1):973-988
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Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot
Rosa María Martínez García et al
Nutr Hosp. 2021 Jul 29
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Associations between Nutrients and Foot Ulceration in Diabetes: A Systematic Review
Nada Bechara et al
Nutrients. 2021 Jul 27;13(8):2576
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Macronutrient and micronutrient intake of individuals with diabetic foot ulceration: A short report
Rebecca Collins et al
J Hum Nutr Diet. 2021 Dec 11
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Macronutrient and micronutrient intake of individuals with diabetic foot ulceration: A short report
Rebecca Collins,Tracy Burrows,Hailey Donnelly,Peta Ellen Tehan
11 December 2021
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