Intensified insulin treatment is associated with improvement in skin microcirculation and ischaemic foot ulcer in patients with type 1 diabetes mellitus: a long-term follow-up study.
Rathsman B, Jensen-Urstad K, Nyström T. Diabetologia; May 2014
In addition to glycaemic control, recent study shows that the effect of CO2 enriched water lies primarily in the vasodilatation which is due to the increase in nitrous oxide formation by CO2 leading to vasodilatation and release of growth factor for angiogenesis which increases oxygen delivery to the area. The improved angiogenesis and oxygenation will result in healing of the ulceration.