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Topical Insulin Accelerates Diabetic Wound Healing

Discussion in 'Diabetic Foot & Wound Management' started by NewsBot, May 30, 2012.

  1. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1

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    Topical Insulin Accelerates Wound Healing in Diabetes by Enhancing the AKT and ERK Pathways: A Double-Blind Placebo-Controlled Clinical Trial
    Maria H. M. Lima, et al
    PLoS ONE 7(5): e36974. doi:10.1371/journal.pone.0036974

     
  2. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Insulin treatment directly restores neutrophil phagocytosis and bactericidal activity in diabetic mice, thereby improving surgical site infection with Staphylococcus aureus
    Hidekazu Yano et al
    Infection and Immunity October 2012
     
  3. davidh

    davidh Podiatry Arena Veteran

    Interesting, but with only 22 subjects (if I'm reading this right) inconclusive.
     
  4. Paul Bowles

    Paul Bowles Well-Known Member

    The number alone doesnt indicate statistical significance. So why inconclusive?
     
  5. davidh

    davidh Podiatry Arena Veteran

    Hi Paul,

    My reasoning is that this is not a representative sample.
    It's an unrepresentative sample which has then been subject to statistical analysis.

    Also, if you read the study there seems to have been a few drop-outs on the way.
    It's what would have been called a pilot study back in the day when I did a research project for my undergrad degree.
    It may point the way forward for more research, but on it's own it can not be considered conclusive.
     
  6. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    This clinical trial is completed, but was only just registered:

    Intensive Insulin Treatment and Ischemic Foot Ulcer
     
  7. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Topical Application of Insulin Accelerates Vessel Maturation of Wounds by Regulating Angiopoietin-1 in Diabetic Mice
    Chaofei Li et al
    International Journal of Lower Extremity Wounds December 2015 vol. 14 no. 4 353-364
     
  8. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effect of local insulin injection on wound vascularization in patients with diabetic foot ulcer.
    Zhang Z, Lv L.
    Exp Ther Med. 2016 Feb;11(2):397-402
     
  9. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Insulin pump for the treatment of diabetes in combination with ulcerative foot infections.
    Fan HJ et al
    J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2):465-70.
     
  10. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effects of insulin on the skin: possible healing benefits for diabetic foot ulcers.
    Emanuelli T et al
    Arch Dermatol Res. 2016 Sep 21.
     
  11. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effect of Systemic Insulin Treatment on Diabetic Wound Healing.
    Vatankhah N et al
    Wound Repair Regen. 2017 Jan 24. doi: 10.1111/wrr.12514
     
  12. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effect of Using Topical Insulin on Improving Pressure Ulcers
    Healing Among Neurological Patients

    Dalia Masoud El-said et al
    IOSR Journal of Nursing and Health Science (IOSR-JNHS)
    e-ISSN: 2320–1959.p- ISSN: 2320–1940 Volume 6, Issue 6 Ver. III. (Nov.- Dec .2017), PP 80-85

     
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