Lipo-PGE for diabetic foot ulcers

NewsBot · May 21, 2010

Members do not see these Ads. Sign Up.
Efficacy by Ulcer Type and Safety of Lipo-PGE(1) for Japanese Patients with Diabetic Foot Ulcers.
Miyata T, Yamada N, Miyachi Y.
J Atheroscler Thromb. 2010 May 19. [Epub ahead of print]

Aim: To examine the efficacy and safety of prostaglandin E(1) incorporated into lipid microspheres (lipo-PGE(1)), Palux(R) Injection, in patients with diabetic foot ulcers classified as ischemic, neuropathic, or neuroischemic at 108 medical institutions throughout Japan.

Methods: A prospective observational study.

Results: The safety and efficacy of the drug were analyzed in 388 and 280 patients, respectively.The overall ulcer size reduction rate at the end of administration was 42.5%: 34.0%, 61.8%, and 33.1% in 71 patients with ischemic ulcer, 70 patients with neuropathic ulcer, and 125 patients with neuroischemic ulcers, respectively. Although lipo-PGE(1) was effective for all the ulcer types examined, the ulcer size reduction rate was significantly higher for neuropathic ulcer than for other types of ulcers. The overall change in the ulcer severity score was -6.1. The change rates in ulcer severity scores were -5.5, -8.4, and -5.2 for ischemic, neuropathic, and neuroischemic ulcers, respectively. The overall efficacy rate was 71.5%. The efficacy rate for neuropathic ulcer was 83.6%, which was significantly higher than for ischemic (68.8%) and neuroischemic (65.3%) ulcers. On the other hand, the incidence of adverse drug reactions was 4.1% (16 cases among 388 patients), indicating that the drug was well tolerated.

Conclusion: Lipo-PGE(1) can be administered relatively safely for diabetic foot ulcers and is effective for all the ulcer types examined, especially for neuropathic ulcer
Click to expand...

NewsBot · May 25, 2010

The treatment of diabetic foot ulcers with uncultured, processed lipoaspirate cells: A pilot study.
Han SK, Kim HR, Kim WK.
Wound Repair Regen. 2010 May 11. [Epub ahead of print]

Human processed lipoaspirate (PLA) cells are relatively easy to obtain in large quantities without cell culture. The purpose of this study was to present the possibility of using uncultured PLA cell autografts for the treatment of diabetic ulcers. An in vitro study was designed initially to determine the effect of PLA cell autografts on the proliferation and collagen synthesis of diabetic fibroblasts (n=4). In a subsequent clinical study, 26 patients with diabetic foot ulcers were treated using PLA cell autografts. Control treatment was also performed in 26 patients. Eight weeks after treatment, the percentages of complete healing and mean healing times were compared. Cell proliferation and collagen synthesis in the PLA cell treatment group were 28 and 44% higher than that in the control group in vitro, respectively. Our clinical study showed that 100% of the PLA cell-treated group and 62% of the control group achieved complete healing. The PLA cell treatment was also superior to the conventional method in terms of the healing time. No adverse events related to the study treatment occurred. Uncultured PLA cell autografts stimulate the activity of diabetic fibroblasts and may offer a simple and effective treatment for diabetic ulcers.
Click to expand...

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

Lipofilling for plantar heloma and metatarsalgia

Lipoma on bottom of big toe joint

Lipodystrophy of the limbs in a diabetes

Alpha Lipoic Acid (ALA) for Diabetic Neuropathy

Fat Grafting (Autologous Lipotransfer) for Diabetic Foot Ulcers

Heel Lipoma Mimicking Plantar Fasciitis

Musculoskeletal problems in lipomyelomeningocele

Share This Page