Antiphospholipid Syndrome and the Foot

NewsBot · May 4, 2023

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Hallux Partial Necrosis Associated with Antiphospholipid Syndrome: The Importance of Early Accurate Diagnosis
Antonio Córdoba-Fernández et al
Life (Basel). 2023 Apr 13;13(4):1009

This study highlights the importance of having a high clinical suspicion of hypercoagulopathy such as antiphospholipid syndrome (APS) in podiatric patients with normal foot pulses and normal standard coagulation tests. APS is an autoimmune disease that is characterized by inflammatory thrombosis in the arteries and veins and obstetric complications such as pregnancy loss. APS usually affects vessels of the lower extremities. We report herein the case of a 46-year-old woman with previous episodes of pre-eclampsia who suffered from partial ischemic necrosis of the hallux of the left foot. After several ischemic episodes of the hallux, with increased risk of toe amputation, the patient was finally diagnosed with APS and treated with specific anticoagulant medication. The patient's symptoms subsided, and toe amputation was prevented. Early accurate diagnosis and appropriate clinical management are critical to providing optimal outcomes and reducing the risk of amputation.
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NewsBot · May 4, 2023

Acute Limb-Threatening Ischemia Associated With Antiphospholipid Syndrome: A Report of Two Cases
Kiwako Suzuki, MD et al
February 20, 2016

Acute limb ischemia results from sudden deterioration in the arterial supply to the limb, occasionally leading to limb loss or fatality. Antiphospholipid syndrome (APS) is known to induce acute limb ischemia among the various etiologies responsible for arterial obstruction. APS is a systemic autoimmune disorder characterized by a combination of arterial and/or venous thrombosis and limb loss. It is often accompanied by a mild-to-moderate thrombocytopenia and elevated titers of antiphospholipid antibodies, including the lupus anticoagulant and the anticardiolipin antibodies. In the present report, we present 2 cases of acute limb ischemia due to APS associated with systemic lupus erythematosus. Angiography revealed arterial obstruction distal to the popliteal artery in both patients, and each patient eventually underwent below-the-knee amputation. Surgeons treating acute limb ischemia should remember APS, although this disease might not be common in daily clinical practice.
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Antiphospholipid Syndrome and the Foot

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Antiphospholipid Syndrome and the Foot

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

Patellofemoral Pain Syndrome Is Associated With Chronic Disease and Allergies

Foot Pain in Leriche Syndrome

Bilateral Foot Pain in a Child With Crouzon Syndrome

Solushin for Medial Tibial Stress Syndrome

Second intermetatarsal space syndrome

Foot Orthoses and Greater Trochanteric Pain Syndrome

Blue toes syndrome

Share This Page

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