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Statins and diabetic foot ulcers

Discussion in 'Diabetic Foot & Wound Management' started by NewsBot, May 15, 2007.

  1. NewsBot

    NewsBot The Admin that posts the news.

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    Statins may be useful in diabetic foot ulceration treatment and prevention.
    Gulcan E, Gulcan A, Erbilen E, Toker S.
    Hospital of Dumlupinar University, Department of Internal Medicine, Kutahya, Turkey.
    Med Hypotheses. 2007 May 10; [Epub ahead of print]
     
  2. NewsBot

    NewsBot The Admin that posts the news.

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    Lipid-lowering therapy in the diabetic foot: seeing the whole iceberg and not just the tip
    Antonoglou C, Papanas N, Maltezos E.
    Curr Vasc Pharmacol. 2012 Sep 24.
     
  3. Admin2

    Admin2 Administrator Staff Member

  4. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Press Release:
    Topical simvastatin shown to accelerate wound healing in diabetes
    Results of new study published in The American Journal of Pathology
    Topical Simvastatin Accelerates Wound Healing in Diabetes by Enhancing Angiogenesis and Lymphangiogenesis
    Jun Asai, Hideya Takenaka, Satoshi Hirakawa, Jun-ichi Sakabe, et al.
    American Journal of Pathology, The Vol. 181, Issue 6, Pages 2217-2224 December 2012
     
  5. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Lower HDL Cholesterol Levels are Associated with the Incidence of Lower-Extremity Amputation in Patients with Diabetic Ulcer/Gangrene
    KAZUKI IKURA, TAKAMICHI SHINJYO, KOU HANAI, YASUKO UCHIGATA, Tokyo, Japan
    American Diabetes Assoication; 73rd Scientific Sessions (2013); Chicago
     
  6. NewsBot

    NewsBot The Admin that posts the news.

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    Effects of lipids and lipoproteins on diabetic foot in people with type 2 diabetes mellitus: A meta-analysis
    Erli Peia et al
    Journal of Diabetes and its Complications; Available online 13 April 2014
     
  7. NewsBot

    NewsBot The Admin that posts the news.

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    Statin therapy and long-term adverse limb outcomes in patients with peripheral artery disease: insights from the REACH registry
    Dharam J. Kumbhani, Ph. Gabriel Steg, Christopher P. Cannon, Kim A. Eagle, Sidney C. Smith, Jr, Shinya Goto, E. Magnus Ohman, Yedid Elbez, Piyamitr Sritara, Iris Baumgartner, Subhash Banerjee, Mark A. Creager, Deepak L. Bhatt, and on Behalf of the REACH Registry Investigators
    Eur Heart J (2014); doi: 10.1093/eurheartj/ehu080
     
  8. NewsBot

    NewsBot The Admin that posts the news.

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    “Statins may be associated with six-week diabetic foot ulcer healing”
    Joshua D. Fox et al
    Wound Repair and Regeneration; Accepted Article
     
  9. NewsBot

    NewsBot The Admin that posts the news.

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    Previous Atorvastatin Treatment and Risk of Diabetic Foot Infection in Adult Patients: A Case-control Study.
    Nassaji M, Ghorbani R, Saboori Shkofte H.
    Wounds. 2017 Apr 27. pii: WNDS20170427-1
     
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    NewsBot The Admin that posts the news.

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    Correlation of HDL cholesterol serum and Wagner’s severity level of diabetic foot ulcers
    Tommy Kartono, Muhammad Nuralim Mallapasi, Mulawardi Mulawardi, Sachraswaty R. Laidding, Meiliati Aminyoto, Prihantono Prihantono
    o 12 (2017)
     
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  12. BEN-HUR

    BEN-HUR Well-Known Member

    Hmm... putting aside the above - here's another perspective - the "prevention better then cure" perspective (in relation to statins):

    Another case for ensuring/promoting positive evidence based lifestyle changes i.e. eating a plant-based diet & regular exercise... thus helping prevent the likes of high cholesterol (hence statin use), diabetes & subsequently... "diabetic foot ulcers"... not to mention, reducing the medical costs to either the government or individual (pending on which part of the world one lives in). After all, aren't statins one of the most (if not, the most) prescribed drugs in the world? Sure, pharmaceutical companies won't like my views - but hey, who gives a @#$%...

    Statins Increase Diabetes Risk by up to 50% in Older Women

    "Statin therapy increases the risk of new-onset diabetes in elderly women by 33%, and the higher the dose, the greater the risk, a new analysis of the observational Australian Longitudinal Study on Women's Health shows.

    "Clearly, statins have beneficial effects, including a reduction in the risk of cardiovascular events; however, the dose-response effect we observed suggests that it may be wise to avoid using higher doses of statins in older women," lead author Mark Jones, MD, senior lecturer, school of public health, the University of Queensland, Brisbane, Queensland, told Medscape Medical News in an email.

    "GPs and their elderly female patients should be aware of the risks," Dr Jones added in a University of Queensland statement, noting that those elderly women taking statins "should be carefully and regularly monitored for increased blood glucose to ensure early detection and management of diabetes."

    And, he and his colleagues suggest, it may be the case that statins could be stopped altogether in some elderly women.

    Women Take Statins on Average, for 6.5 Years.

    The new analysis included 8372 Australian women aged between 76 and 82 years at baseline who were followed for 10 years; it is published in the March issue of Drugs and Aging.

    Dr Jones and colleagues note that the majority of participants in statin trials have been males and that females, especially elderly ones, have been underrepresented.

    "Our group has expertise and experience in women's health, including being involved with the Australian Longitudinal Study on Women's Health for the past 20 years, and we focused on the older cohort of women [in this study] because we thought this is a population that has generally not been included in clinical trials," Dr Jones explained to Medscape Medical News... "

     
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