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The Certainty of Uncertainty in Medicine

Discussion in 'General Issues and Discussion Forum' started by BEN-HUR, May 25, 2015.

  1. BEN-HUR

    BEN-HUR Well-Known Member

    Members do not see these Ads. Sign Up.
    Found the following article fascinating: The Certainty of Uncertainty in Medicine (Medscape article - hence you need to log-in). It is somewhat related to this other recent thread: Accuracy of medical press releases (which has a more press/news exaggeration perspective)... whilst the article of this thread has a more research perspective...

    Fascinating topic... unfortunately, it's not just medicine which has suffered the above traits i.e. areas relating to Biology have also suffered (but best leave that apparent thorn alone).

    I would assume that Podiatry is faring quite well (from my experience)... however, there are other fields i.e. Chiropractic, which have had their inquiries (at least within Australia) of which haven't fared so well.
  2. BEN-HUR

    BEN-HUR Well-Known Member

    Here is that John Ioannidis paper cited in the previous post:

    Why Most Published Research Findings Are False (apparently... "it has become the most accessed article in the history of the Public Library of Science, known as PLOS")...

    Hopefully things have improved since the publication of the above; however, going by the following paper he still alleges that an estimated "85%" of research resources are wasted...

    Another (more recent i.e. 2014) John Ioannidis paper on a related issue:

    How to Make More Published Research True...

  3. Excellent Matt - the two best posts you've written to date!
  4. I should qualify the last post by saying I enjoy reading your contributions, Matt. It just takes a while!
  5. BEN-HUR

    BEN-HUR Well-Known Member

    Thanks Mark... reminds me of one of my favourite Mark Twain quotes...


    As another saying goes... "all good things take time" ;)
  6. daisyboi

    daisyboi Active Member

  7. BEN-HUR

    BEN-HUR Well-Known Member

    Another fascinating article recently published in relation to this topic/thread... reducing/assessing the processes that may lead scientists to stop fooling themselves (& subsequently others) i.e. elimination of "motivated reasoning" & "confirmation bias" :
    The Trouble With Scientists (http://nautil.us/issue/24/error/the-trouble-with-scientists)...

  8. BEN-HUR

    BEN-HUR Well-Known Member

    I've been sitting on this article for a while... it's just a news article... but have revisited it today & the content is still interesting (for this thread). It discusses similar issues to what has been discussed above (i.e. poor science research/interpretation of data). The reason I've been sitting on it is that I don't want to be seen as someone knocking "science"... I love science... but it disturbs me when I see science abuse or science misconduct... particularly when it is deliberate. Podiatry Arena has discussed quite a number of papers which has been tainted with the likes of poor science research/interpretation of data... particularly within the field of biomechanics (i.e. barefoot, footwear, orthotic related topics).

    William Reville: Something has gone very wrong with science (http://www.irishtimes.com/news/scie...ng-has-gone-very-wrong-with-science-1.2245846)

    Quite sobering views... but views we (science) must face, acknowledge... & act upon to resolve the problems.

    Problems of which may include the following (views of Richard Horton, editor-in-chief of the Lancet)...

    Professor John Ioannidis (cited in previous posts) gets a mention again...

    Now with the above said (within a news article)... there is a formal blog related to this topic... called:
    Retraction Watch (http://retractionwatch.com/). A blog that reports on the retractions of scientific papers (science misconduct etc...), such as...

    High-profile biologist is suspended after two investigations found he “breached his duty of care”, committed “misconduct” ...

    Here is the Wikipedia page on Retraction Watch (https://en.wikipedia.org/wiki/Retraction_Watch)... which is quite interesting in itself...

    ... as well as humorous...

    Retraction Watch became quite busy... more than what they thought...

  9. drhunt1

    drhunt1 Well-Known Member

    Reminds me that when other Podiatrists refute my findings in a pilot study on growing pains, simply because I did not use a placebo orthotic, (the efficacy which has been challenged here at PA), it begs the question about what we really are interested in...better patient outcomes or ego?
  10. BEN-HUR

    BEN-HUR Well-Known Member

    ?Evidence-based medicine has been hijacked:? A confession from John Ioannidis (http://retractionwatch.com/2016/03/...en-hijacked-a-confession-from-john-ioannidis/)

  11. BEN-HUR

    BEN-HUR Well-Known Member

    This article found in QUARTZ:

    Many scientific "truths" are, in fact, false (http://qz.com/638059/many-scientific-truths-are-in-fact-false/)

  12. BEN-HUR

    BEN-HUR Well-Known Member

    Article from Retraction Watch:
    Retractions aren't enough: Why science has bigger problems (http://retractionwatch.com/2016/05/19/retractions-arent-enough-why-science-has-bigger-problems/)

  13. BEN-HUR

    BEN-HUR Well-Known Member


  14. BEN-HUR

    BEN-HUR Well-Known Member

    Yes, drowning in data overload (& what to believe). Interesting, albeit frustrating trends within scientific/medical research (i.e. cherry picking data to suit one's agenda)…
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