Topical 5% potassium permanganate for diabetic foot ulcers

NewsBot · Feb 13, 2018

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Topical 5% potassium permanganate solution accelerates the healing process in chronic diabetic foot ulcers.
Delgado-Enciso I et al
Biomed Rep. 2018 Feb;8(2):156-159. doi: 10.3892/br.2018.1038.

Potassium permanganate has been reported to be an effective treatment for certain types of wounds. The aim of the present study was to evaluate the use of potassium permanganate in the treatment of diabetic foot ulcers. A single-blind, randomized, controlled clinical trial was conducted on patients with type 2 diabetes mellitus that presented with a foot ulcer persisting for >3 months. The control group (n=10) was treated with the current standard treatment, which comprises of measures for reducing pressure in the ulcerated area, daily cleansing of the ulcer with potable water and antiseptic wash solution, and the application of a disinfectant solution on the entire surface area of the ulcer; while the intervention group (n=15) received the standard treatment plus 5% topical potassium permanganate solution applied once a day for 21 days. In the intervention group, 1 patient did not tolerate the treatment and was eliminated from the study on the first day. The remaining patients tolerated the interventions well. At the end of the treatment period, ulcers in the control group had decreased by 38% whereas those in the intervention group decreased by 73% (P<0.009). The degree of decrease was also investigated; the ulcer size was ≥50% decreased in 40% of patients in the control group and in 86% of patients in the intervention group (P=0.02). In conclusion, the results of the present study indicate that topical potassium permanganate is well tolerated and significantly accelerates the healing process of diabetic foot ulcers.
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William Fowler · Feb 13, 2018

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Topical 5% potassium permanganate solution.
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Thats a blast from the past!

NewsBot · Jun 21, 2022

Potassium permanganate: A ‘Desert Island drug’ in Dermatology
Vijayasankar Palaniappan,Kaliaperumal Karthikeyan
15 May 2022

Potassium permanganate (KMnO4) is an over the-counter available astringent with oxidising and antiseptic property used by the dermatologists since ages. It is often used as compresses and baths for various exudative dermatoses. Its advantages include lower cost, good healing rate and reduced allergenic potential. Chemical burns and associated staining of cloths and ceramics are the two important cutaneous adverse effects encountered with its use. Due to the its easy availability, chances for homicidal or accidental ingestion of this drug are high. The focus of this article is to increase awareness among dermatologists about is clinical use, adverse effects, systemic toxicity and its management.
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