Therapeutic efficacy of ozone in patients with diabetic foot.
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Eur J Pharmacol. 2005 Sep 27
Martinez-Sanchez G, Al-Dalain SM, Menendez S, Re L, Giuliani A, Candelario-Jalil E, Alvarez H, Fernandez-Montequin JI, Leon OS.
Center of Studies for Research and Biological Evaluation (CEIEB-IFAL), University of Havana, Havana 10400, Cuba.
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The Hyperbaric Chamber at Prince of Wales Hospital at Randwick has had excellent results with ulcer treatments over the past 10 years + using Oxygen Therapy. The patient is in the chamber for about 3 hours per session.
Treatment for White Tail Spider bites where severe ulceration has occurred.
Rapid healing of fractures
There are disadvantages
Possible rupture of ear drum very minor occurance
Don Scott -
Hyperbaric Oxygen and Innocent White Tailed Spider
I too have seen some good results from Hyperbaric Therapy, but is it the oxygen or the fact that they are resting and recieving intense care and committed etc. to spending 3 hours 3 times or more per week for upto 6 weeks in a decompression chamber?
No one has done the randomised control trial yet!
Re: the white tail spider. It has been shown to be an innocent bystander in the causation of these necrotising ulcers. The ABC Catalyst show reports on its innocence, all ulcers in this study traced back to something else: a range of conditions from Golden Staf infections, infected ulcers even one case of skin cancer...and all misidentified by doctors as White Tailed Spider bites.
Further story at mydr.com.auLast edited: Oct 7, 2005 -
I have had at least five patient who were bitten by the White Tail Spider and they all had ulcerations around the bite site. They were sent to P of W for Tx.
There is one theory that this spider has the ability to take on the venom of the spiders it devours.
The hyperbacric chamber at Prince of Wales Hospital (Randwick Sydney) is used for diver recovery, Pseudoarthitis, crush fractures, ulcer management, sports injuries (See today's Sunday Telegraph Balmain Footballer had several sessions page 55. He also had 11 needles) and in special cased they can conduct major surgery inside the chamber. The chamber can seat up to six patients. It's bloody big and it was run by qualified Hyperbaric Doctor (Dr Michael Bennett) and specially trained nursing staff.
100% Oxygen therapy does not need any more randomised trial. I have 1996 publications from USA and Australia on Hyperbaric Medicine
Current acute applications for HBOT are
Acute smoke inhalation, Decompression Sickness, Osteomyelitis, Air or Gas Embolism, Exceptional Blood Loss, Gas gangrene, Cyanide posioning, Anaerobic infections
As Therapy
Skin graft flaps, Decubitus Ulcers, Diabetic Ulcers, Burns victims, Pseudoarthritis (Non union fraqctures), Peripheral Vascular Disease, Necrotising soft tissue infections.
It works!
Don Scott -
There is a big difference between the use of hyperbaric oxygen and the application of ozone (what the first research abstract was about in this thread).
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I realise these are two different modes of treatment and each have merit.
Where is Ozone therapy used in Australia?
Don Scott -
Don, There may be trials re: decompression sickness, smoke inhalation etc. but none that I am aware of for wound healing. Yes there is alot published, but mainly case studies. There are some studies using the VACS which "pulls"
blood and oxygen to a wound.
And the white tailed spider is incapable of causing a necrotising ulcer, as the previous links stated.
Re Ozone therapy, I use to use it 18 years ago primarily in the treatment of venous leg ulcers before it was realised that compression therapy worked much better.
We used a box that covered the wound and was connected into an Ozone generating machine that plugged into the wall -
What about the Amy Compression system reduction in lymphatic disorders
Don -
Dear Admin
Is Ozone theraputic? I was under the impression that Ozone (03) inhibited wound healing.
Ref; Toxicol Lett. 2005 Aug 26;
Modulation of cutaneous wound healing by ozone: Differences between young and aged mice.
Lim Y, Phung AD, Corbacho AM, Aung HH, Maioli E, Reznick AZ, Cross CE, Davis PA, Valacchi G.
Department of Internal Medicine, School of Medicine, UC Davis, Davis CA, USA.
Cutaneous tissues are frequently exposed to prooxidative environments, including UV radiation and air pollutants. Among the latter, ozone (O(3)) is of particular concern because of its high and dominating presence in photochemical smog. It is well known that O(3) depletes small molecular weight antioxidants, oxidizes proteins, induces lipid peroxidation and activates cellular responses in various tissues. Using an in vivo model (SKH-1 hairless mice), the interaction between O(3) exposure (0.5ppmx6h/day) and age was examined in relation to cutaneous wound healing. Compared to younger (8 weeks) mice, older (18 months) mice exposed to O(3) (day 0 to day 9 after wounding) exhibited delayed wound closure, increased lipid peroxidation (measured as 4-HNE protein adducts) and protein oxidation (measured as carbonyls concentration) and decreased levels of P-IkappaBalpha and TGFbeta protein. These findings support the hypothesis that oxidant pollutant exposure and age interact so as to disrupt normal wound healing processes.
PMID: 16129572 [PubMed - as supplied by publisher
confused! Dave Smith -
Efficacy of Ozone-Oxygen Therapy for the Treatment of Diabetic Foot Ulcers.
Wainstein J, Feldbrin Z, Boaz M, Harman-Boehm I.
Diabetes Technol Ther. 2011 Jul 13. [Epub ahead of print]
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Effect of Normobaric Hyperoxic Therapy on Tissue Oxygenation in Diabetic Feet: A Pilot Study
Kyung-Chul Moon et al
Journal of Plastic, Reconstructive & Aesthetic Surgery; Available online 15 July 2014
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Increased growth factors play a role in wound healing promoted by noninvasive oxygen-ozone therapy in diabetic patients with foot ulcers.
Zhang J, Guan M, Xie C, Luo X, Zhang Q, Xue Y.
Oxid Med Cell Longev. 2014;2014:273475.
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Ozone therapy for treating foot ulcers in people with diabetes.
Liu J, Zhang P, Tian J, Li L, Li J, Tian JH, Yang K.
Cochrane Database Syst Rev. 2015 Oct 27;10:CD008474
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Ozone therapy effectiveness in patients with ulcerous lesions due to diabetes mellitus.
Rosul MV et al
Wiad Lek. 2016;69(1):7-9.
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Ozone therapy for the treatment of chronic wounds: A systematic review
Erin Fitzpatrick, Olivia J Holland, Jessica J Vanderlelie
International Wound Journal: 13 March 2018
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Ozone therapy for diabetic foot.
Kushmakov R et al
Med Gas Res. 2018 Sep 25;8(3):111-115. doi: 10.4103/2045-9912.241076. eCollection 2018 Jul-Sep.
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Efficacy of comprehensive ozone therapy in diabetic foot ulcer healing
lMortezaIzadiaRaminKheirjouaRoyaMohammadpourbMohammad HassanAliyoldashibSaeedreza JamaliMoghadamcFarzinKhorvashdNematollah JonaidiJafarieShahramShirvanifNahidkhalilie
Diabetes & Metabolic Syndrome: Clinical Research & Reviews; 1 December 2018
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Ozone Therapy on Reduction of Bacterial Colonies and Acceleration of Diabetic Foot Ulcer Healing
Kasmawati Kadir, Yuliana Syam, Saldy Yusuf, Masriani Zainuddin
Home Healthc Now. Jul/Aug 2020;38(4):215-220
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Ozone therapy as an alternative method for the treatment of diabetic foot ulcer: a case report
Navid Faraji et al
J Med Case Rep. 2021 May 13;15(1):234
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A systematic review of ozone therapy for treating chronically refractory wounds and ulcers
Qing Wen et al
Int Wound J. 2021 Oct 6
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Prospective Comparative Observational Study of Safety and Efficacy of Topical Ozone Gas Therapy in Healing of Diabetic Foot Ulcers versus Only Conventional Wound Management
Suchin Dhamnaskar et al
Surg J (N Y). 2021 Sep 14;7(3):e226-e236
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BENEFITS OF OZONE THERAPY IN THE TREATMENT OF FOOT ULCERS IN PEOPLE WITH DIABETES MELLITUS
Francisco Walyson Batista, Thiago Araújo, Maria Girlane Sousa Albuquerque Brandão, Vanessa Aguiar Ponte
ESTIMA, Brazilian Journal of Enterostomal Therapy, 2021
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Effectiveness and Safety of Ozone Therapy for Dermatological Disorders: A Literature Review of Clinical Trials
Andressa Urbano Machado, Renata Vidor Contri
Review Indian J Dermatol. 2022 Jul-Aug;67(4):479
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This clinical trial was just registered:
Effect of Topical Ozone on The Healing Diabetic Foot Ulcer
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Use of Ozone Therapy in Diabetic Foot Ulcers
Álvaro Astasio-Picado et al
J. Pers. Med. 2023, 13(10), 1439; https://doi.org/10.3390/jpm13101439
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Use of Ozone Therapy in Diabetic Foot Ulcers
Álvaro Astasio-Picado et al
J Pers Med. 2023 Sep 27;13(10):1439
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Healing refractory livedoid vasculopathy-related skin ulcers by ozone therapy: a case-based review
Gulsah Yasa Ozturk, Burhan Fatih Kocyigit
Rheumatol Int. 2023 Nov 24.
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Evaluation of the healing potential of short-term ozone therapy for the treatment of diabetic foot ulcers
Haojie Sun et al
Front Endocrinol (Lausanne). 2024 Jan 15:14
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Successful treatment of a high-risk diabetic foot ulcer by ozone therapy and collagen powder: A case report
Hooman Mohammad Talebi et al
Clin Case Rep. 2024 Apr 1;12(4):e8728.
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