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Efficacy of ozone in patients with diabetic foot ulcers

Discussion in 'Diabetic Foot & Wound Management' started by admin, Oct 5, 2005.

  1. admin

    admin Administrator Staff Member

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    Therapeutic efficacy of ozone in patients with diabetic foot.
    Eur J Pharmacol. 2005 Sep 27
    Martinez-Sanchez G, Al-Dalain SM, Menendez S, Re L, Giuliani A, Candelario-Jalil E, Alvarez H, Fernandez-Montequin JI, Leon OS.
    Center of Studies for Research and Biological Evaluation (CEIEB-IFAL), University of Havana, Havana 10400, Cuba.
  2. Don ESWT

    Don ESWT Active Member

    The Hyperbaric Chamber at Prince of Wales Hospital at Randwick has had excellent results with ulcer treatments over the past 10 years + using Oxygen Therapy. The patient is in the chamber for about 3 hours per session.

    Treatment for White Tail Spider bites where severe ulceration has occurred.
    Rapid healing of fractures

    There are disadvantages
    Possible rupture of ear drum very minor occurance

    Don Scott
  3. Tuckersm

    Tuckersm Well-Known Member

    Hyperbaric Oxygen and Innocent White Tailed Spider

    I too have seen some good results from Hyperbaric Therapy, but is it the oxygen or the fact that they are resting and recieving intense care and committed etc. to spending 3 hours 3 times or more per week for upto 6 weeks in a decompression chamber?
    No one has done the randomised control trial yet!

    Re: the white tail spider. It has been shown to be an innocent bystander in the causation of these necrotising ulcers. The ABC Catalyst show reports on its innocence, all ulcers in this study traced back to something else: a range of conditions from Golden Staf infections, infected ulcers even one case of skin cancer...and all misidentified by doctors as White Tailed Spider bites.

    Further story at mydr.com.au
    Last edited: Oct 7, 2005
  4. Don ESWT

    Don ESWT Active Member

    I have had at least five patient who were bitten by the White Tail Spider and they all had ulcerations around the bite site. They were sent to P of W for Tx.

    There is one theory that this spider has the ability to take on the venom of the spiders it devours.

    The hyperbacric chamber at Prince of Wales Hospital (Randwick Sydney) is used for diver recovery, Pseudoarthitis, crush fractures, ulcer management, sports injuries (See today's Sunday Telegraph Balmain Footballer had several sessions page 55. He also had 11 needles) and in special cased they can conduct major surgery inside the chamber. The chamber can seat up to six patients. It's bloody big and it was run by qualified Hyperbaric Doctor (Dr Michael Bennett) and specially trained nursing staff.

    100% Oxygen therapy does not need any more randomised trial. I have 1996 publications from USA and Australia on Hyperbaric Medicine

    Current acute applications for HBOT are
    Acute smoke inhalation, Decompression Sickness, Osteomyelitis, Air or Gas Embolism, Exceptional Blood Loss, Gas gangrene, Cyanide posioning, Anaerobic infections

    As Therapy
    Skin graft flaps, Decubitus Ulcers, Diabetic Ulcers, Burns victims, Pseudoarthritis (Non union fraqctures), Peripheral Vascular Disease, Necrotising soft tissue infections.

    It works!

    Don Scott
  5. admin

    admin Administrator Staff Member

    There is a big difference between the use of hyperbaric oxygen and the application of ozone (what the first research abstract was about in this thread).
  6. Don ESWT

    Don ESWT Active Member

    I realise these are two different modes of treatment and each have merit.

    Where is Ozone therapy used in Australia?

    Don Scott
  7. Tuckersm

    Tuckersm Well-Known Member

    Don, There may be trials re: decompression sickness, smoke inhalation etc. but none that I am aware of for wound healing. Yes there is alot published, but mainly case studies. There are some studies using the VACS which "pulls"
    blood and oxygen to a wound.

    And the white tailed spider is incapable of causing a necrotising ulcer, as the previous links stated.

    Re Ozone therapy, I use to use it 18 years ago primarily in the treatment of venous leg ulcers before it was realised that compression therapy worked much better.

    We used a box that covered the wound and was connected into an Ozone generating machine that plugged into the wall
  8. Don ESWT

    Don ESWT Active Member

    What about the Amy Compression system reduction in lymphatic disorders
  9. David Smith

    David Smith Well-Known Member

    Dear Admin

    Is Ozone theraputic? I was under the impression that Ozone (03) inhibited wound healing.
    Ref; Toxicol Lett. 2005 Aug 26;
    Modulation of cutaneous wound healing by ozone: Differences between young and aged mice.

    Lim Y, Phung AD, Corbacho AM, Aung HH, Maioli E, Reznick AZ, Cross CE, Davis PA, Valacchi G.

    Department of Internal Medicine, School of Medicine, UC Davis, Davis CA, USA.

    Cutaneous tissues are frequently exposed to prooxidative environments, including UV radiation and air pollutants. Among the latter, ozone (O(3)) is of particular concern because of its high and dominating presence in photochemical smog. It is well known that O(3) depletes small molecular weight antioxidants, oxidizes proteins, induces lipid peroxidation and activates cellular responses in various tissues. Using an in vivo model (SKH-1 hairless mice), the interaction between O(3) exposure (0.5ppmx6h/day) and age was examined in relation to cutaneous wound healing. Compared to younger (8 weeks) mice, older (18 months) mice exposed to O(3) (day 0 to day 9 after wounding) exhibited delayed wound closure, increased lipid peroxidation (measured as 4-HNE protein adducts) and protein oxidation (measured as carbonyls concentration) and decreased levels of P-IkappaBalpha and TGFbeta protein. These findings support the hypothesis that oxidant pollutant exposure and age interact so as to disrupt normal wound healing processes.

    PMID: 16129572 [PubMed - as supplied by publisher

    confused! Dave Smith
  10. NewsBot

    NewsBot The Admin that posts the news.

    Efficacy of Ozone-Oxygen Therapy for the Treatment of Diabetic Foot Ulcers.
    Wainstein J, Feldbrin Z, Boaz M, Harman-Boehm I.
    Diabetes Technol Ther. 2011 Jul 13. [Epub ahead of print]
  11. NewsBot

    NewsBot The Admin that posts the news.

    Effect of Normobaric Hyperoxic Therapy on Tissue Oxygenation in Diabetic Feet: A Pilot Study
    Kyung-Chul Moon et al
    Journal of Plastic, Reconstructive & Aesthetic Surgery; Available online 15 July 2014
  12. NewsBot

    NewsBot The Admin that posts the news.

    Increased growth factors play a role in wound healing promoted by noninvasive oxygen-ozone therapy in diabetic patients with foot ulcers.
    Zhang J, Guan M, Xie C, Luo X, Zhang Q, Xue Y.
    Oxid Med Cell Longev. 2014;2014:273475.
  13. NewsBot

    NewsBot The Admin that posts the news.

    Ozone therapy for treating foot ulcers in people with diabetes.
    Liu J, Zhang P, Tian J, Li L, Li J, Tian JH, Yang K.
    Cochrane Database Syst Rev. 2015 Oct 27;10:CD008474
  14. NewsBot

    NewsBot The Admin that posts the news.

    Ozone therapy effectiveness in patients with ulcerous lesions due to diabetes mellitus.
    Rosul MV et al
    Wiad Lek. 2016;69(1):7-9.
  15. NewsBot

    NewsBot The Admin that posts the news.

    Ozone therapy for the treatment of chronic wounds: A systematic review
    Erin Fitzpatrick, Olivia J Holland, Jessica J Vanderlelie
    International Wound Journal: 13 March 2018
  16. NewsBot

    NewsBot The Admin that posts the news.

    Ozone therapy for diabetic foot.
    Kushmakov R et al
    Med Gas Res. 2018 Sep 25;8(3):111-115. doi: 10.4103/2045-9912.241076. eCollection 2018 Jul-Sep.

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