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Osteoarthritis and obesity: more than a mechanical link

Discussion in 'Gerontology' started by Hylton Menz, Oct 19, 2006.

  1. Hylton Menz

    Hylton Menz Guest

    Members do not see these Ads. Sign Up.
    Very interesting editorial from Annals of the Rheumatic Diseases, which can be downloaded for free:

    Obesity and osteoarthritis: more complex than predicted!

    ...These patterns of joint involvement suggest that joint damage may be caused by systemic factors such as adipose factors, so called adipokines, which may provide a metabolic link between obesity and osteoarthritis...So, recent data strengthen the hypothesis that osteoarthritis is a systemic disorder in which dysregulation of lipid homeostasis can be one of the pathophysiological mechanisms leading to osteoarthritis...

  2. C Bain

    C Bain Active Member

    Hi All,

    Very interesting article worth another read later when I will have more time to take it in.



    PS. One small aside. This came up in My Yahoo? Blocked by yahoo as forbidden serve and URL? Never happened before? Got here alright when I came back here though!

    PPS. Has anyone ever done any work on Mechanical loading of joints caused by access weight I wonder. Engineering, steel joints friction heat increase with load? Could this happen in organic joints I wonder?
  3. NewsBot

    NewsBot The Admin that posts the news.

    Why is obesity associated with osteoarthritis? Insights from mouse models of obesity.
    Griffin TM, Guilak F.
    Biorheology. 2008;45(3-4):387-98.
  4. NewsBot

    NewsBot The Admin that posts the news.

    A systematic review on changed biomechanics of lower extremities in obese individuals: a possible role in development of osteoarthritis.
    Runhaar J, Koes BW, Clockaerts S, Bierma-Zeinstra SM.
    Obes Rev. 2011 Aug 3. doi: 10.1111/j.1467-789X.2011.00916.x. [Epub ahead of print]
  5. NewsBot

    NewsBot The Admin that posts the news.

  6. NewsBot

    NewsBot The Admin that posts the news.

    Press Release:
    Weight loss may prevent, treat osteoarthritis in obese patients
    Obesity may trigger biomechanical changes, pathways that contribute to osteoarthritis

    Obesity and Osteoarthritis: More Than Just Wear and Tear
    Ryan C. Koonce and Jonathan T. Bravman
    J Am Acad Orthop Surg March 2013 ; 21:161-169.; doi:10.5435/JAAOS-21-03-161
  7. NewsBot

    NewsBot The Admin that posts the news.

    Press Release:
    Scientists Find Obesity Alone Does Not Cause Arthritis in Animals
  8. NewsBot

    NewsBot The Admin that posts the news.

    Individuals with primary osteoarthritis have different phenotypes depending on the affected joint - a case control study from southern sweden including 514 participants.
    Karlsson MK, Karlsson C, Magnusson H, Cöster M, von Schewelov T, Nilsson JÅ, Brudin L, Rosengren BE
    Open Orthop J. 2014 Dec 29;8:450-6.

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