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Is Alzheimer's a New Form of Diabetes?

Discussion in 'General Issues and Discussion Forum' started by admin, Dec 20, 2005.

  1. admin

    admin Administrator Staff Member


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    WebMD are reporting:
    Rivera, E. Journal of Alzheimer's Disease, November 2005; vol 7: pp 1-20. News release
     
  2. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    More on Alzheimer's

    Couple of press releases on breakthroughs in the understanding of Alzheimers:
    From Science Daily:
    From Yahoo! Health:
     
  3. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Further link between diabetes and Alzheimer's

    ScienceDaily are reporting:
    Diabetes Drug Shows Promise In Treating Alzheimer's
     
  4. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Diabetes may be linked to Alzheimer's

    CTV are also reporting:
    Diabetes may be linked to Alzheimer's: studies
     
  5. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Red Wine Prevents Alzheimer's

    Ivanhone Newswire are reporting:
    Red Wine Prevents Alzheimer's
    Full story
     
  6. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Press Release:
    MayoClinic Highlights Possible Diabetes And Alzheimer's Connection
    www.mayoclinic.com
     
  7. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Another new report on this:
    Could Alzheimer’s be a Form of Diabetes?
    (Ivanhoe Newswire) -- Could a new form of diabetes be to blame for the memory loss of Alzheimer’s disease?

     
  8. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Sugary Beverages May Increase Alzheimer's Risk

    Excess drinking of sugary beverages like soda may increase the risk of Alzheimer's disease, suggests new research in mice. Although the exact mechanisms aren't known, obesity and diabetes are both associated with higher incidences of Alzheimer's.

    More...
     
  9. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    ScienceDaily are reporting:
    Diabetes Link To Alzheimer's Disease Explained
    Full story
     
  10. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    The pathological interaction between diabetes and presymptomatic Alzheimer's diseaseNeurobiology of Aging; Available online 26 March 2008
    Joseph R. Burdo, Qi Chen, Nigel A. Calcutt, David Schubert
     
  11. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Science Daily are reporting:
    Insulin Is A Possible New Treatment For Alzheimer's
    Full story
     
  12. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Press Release:
    UB Study Suggests That Insulin Could Be Potential Therapy for Alzheimer's Disease
     
  13. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Press Release:
    Researchers Identify How a Gene Linked to Both Alzheimer’s Disease and Type 2 Diabetes Works

     
  14. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Amyloid-β and Tau Pathology of Alzheimer’s Disease Induced by Diabetes in an Animal Model
    Claudine L. Bitel, Chinnaswamy Kasinathan, Rajesh H. Kaswala, William L Klein, Peter H. Frederikse
    Journal of Alzheimer's (in press)
     
  15. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Press Release:
    Diabetes Drug Could Help Fight Alzheimer's Disease
     
  16. admin

    admin Administrator Staff Member

  17. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Press Release:
    Salk study finds diabetes raises levels of proteins linked to Alzheimer's features
    Mouse model may provide clues on mechanism linking diabetes and aging to Alzheimer's
     
  18. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Press Release:
    Type II diabetes and the Alzheimer's connection
    Scientists study interactions between two molecules thought to play critical roles in these diseases
     
  19. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Press Release:
    Diabetes drug may reverse Alzheimer's and enters major clinical trial
     
  20. NewsBot

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    Articles:
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    Epigenetic mechanisms linking diabetes and synaptic impairments
    Jun Wang et al
    Diabetes October 23, 2013
     
  21. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Press Release:
    Amyloid Formation May Link Alzheimer Disease and Type 2 Diabetes
    Islet Amyloid Peptide Found in Human Brain Senile Plaques with Beta-Amyloid, According to Study Published in The American Journal of Pathology
     
  22. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    News Release
    Joslin Scientists Find Direct Link between Insulin Resistance in the Brain and Behavioral Disorders
    Study in mice identifies mechanism that lowers levels of dopamine and heightens behavior suggesting anxiety and depression
     
  23. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Insulin Resistance in Alzheimer Disease: Is Heme Oxygenase-1 an Achille's Heel?
    Barone E, Allan Butterfield D
    Neurobiol Dis. 2015 Feb 27
     
  24. NewsBot

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    Articles:
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    Press Release:
    Trinity researchers report major breakthrough in understanding Alzheimer's disease
     
  25. NewsBot

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    Articles:
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    An updated Meta-Analysis of cohort studies: diabetes and risk of Alzheimer’s disease
    Jieyu Zhang et al
    Diabetes Res Clin prac; Article in Press
     
  26. NewsBot

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    Articles:
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    PUBLIC RELEASE: 23-MAR-2017
    Insulin resistance may lead to faster cognitive decline
    Executive function and memory are particularly vulnerable to the effects of insulin resistance, Tel Aviv University researchers say

     
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    Articles:
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    PUBLIC RELEASE: 7-AUG-2018
    Alzheimer's disease and type 2 diabetes: Hope for inhibitors against amyloid plaques
    Designed peptides as potential inhibitors of amyloid plaques


    Effective therapeutics to counteract the formation of amyloid plaques in Alzheimer's disease and type 2 diabetes are not yet available. Scientists at the Technical University of Munich (TUM) have now come a little bit closer to a solution: They have described a new class of designed macrocyclic peptides that are highly potent inhibitors of amyloid formation.

    Amyloid plaques, which are protein deposits, play a crucial role in the development of Alzheimer's disease and type 2 diabetes. Several teams of scientists around the world are working on finding ways to prevent amyloid plaque formation in the human brain.

    The research team of Aphrodite Kapurniotu, Professor for Peptide Biochemistry (TUM) has been working on an idea for some time now in collaboration with the teams of Professor Martin Zacharias (TUM), Professor Gerhard Rammes (TUM Rechts der Isar Hospital) and Professor Jürgen Bernhagen (Institute for Stroke and Dementia Research (ISD) at Ludwig Maximilian University (LMU)). The researchers present now macrocyclic peptides (MCIPs) as potent inhibitors of amyloid formation; they reported their results in the journal Angewandte Chemie. The work has been supported by Deutsche Forschungsgemeinschaft (DFG) collaborative research center SFB 1035.

    New class of amyloid inhibitors

    In its new study, the team presents macrocyclic peptides, developed as a new class of amyloid inhibitors. "We have discovered an MCIP that is stable in human blood plasma and can also overcome the human blood-brain barrier in an in vitro cell culture model," explains Professor Kapurniotu. She adds: "So far we were 'only' able to demonstrate these properties in the test tube - thus further research is necessary. But these are two highly desirable properties for inhibitors of Alzheimer's amyloid."

    TUM has already applied for a patent for the newly developed macrocyclic peptides. "They could be a good alternative to the currently pursued antibody-based approaches as therapeutics against Alzheimer's amyloid plaque formation because they are easy to produce, have promising properties and, due to their peptidic nature, they will be significantly cheaper than antibodies," says Professor Kapurniotu.

    "Therefore, further investigations are now planned to verify whether the MCIPs are also effective in in vivo models. Furthermore, the MCIPs could also be suitable as templates for the development of small molecule peptidomimetics (molecules mimicking peptide chains), which might also find application as anti-amyloid drugs in Alzheimer's and type 2 diabetes.
     
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